Results 181 to 190 of about 101,283 (342)

Adverse Outcome Pathways Applied to Space Radiation Research

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Long‐duration spaceflight exposes astronauts to various stressors that can alter human physiology, potentially causing immediate and long‐term health effects. These stressors can damage biomolecules, cells, tissues, and organs, leading to adverse outcomes.
Vinita Chauhan, Veronica S. Grybas, Devyn Hoopfer, Casey Higginson, Elizabeth A. Ainsbury, Omid Azimzadeh, Afshin Beheshti, Steve Blattnig, Marjan Boerma, Sylvain V. Costes, Stephen Doty, Christelle Adam‐Guillermin, Nobuyuki Hamada, Patricia Hinton, Janice L. Huff, Robert Reynolds, Ruth C. Wilkins, Scott Wood, Carole L. Yauk   +18 more
wiley   +1 more source

Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis

Exploration, EarlyView.
NaCr promotes KCr to impede the inflammatory progression of ulcerative colitis. KCr induces mitophagy by activating the PINK1/PARKIN pathway to restrict NLRP3 inflammasome activation, thereby decreasing the production and release of various inflammatory cytokines, such as IL‐1β and TNF‐α. KCr induces mitophagy and inhibits NLRP3 inflammasome activation
Tongtong Liu, Binyan Lin, Ying Zhang, Jiayu Su, Xiaochao Hu, Xuan Wang, E‐Hu Liu, Shijia Liu   +7 more
wiley   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, EarlyView.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

Claudin expression in rectal well-differentiated endocrine neoplasms (carcinoid tumors)

, 1994
Okabe
openalex   +2 more sources

Impacts of Diets and Food Plans in Health and Diseases—A Narrative Review

Food Safety and Health, EarlyView.
This review emphasizes different diet types, providing insights into their nutritional content and health effects. Vegetarian and vegan diets, ketogenic diets, Mediterranean diets, Western diets, pescatarian diets, flexitarian diets, and territorial diversified diets are discussed, highlighting their influences on health, and diseases.
Md. Mahbubar Rahman, Manisha Pandit, Bhawana Thukral, Morshed M. Khandoker   +3 more
wiley   +1 more source

Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasms

, 2007
Mitsuaki Ishida, Ryoji Kushima, Tokuhiro Chano, Hidetoshi Okabe   +3 more
openalex   +2 more sources

Ramucirumab‐containing chemotherapy for patients with gastrointestinal neuroendocrine carcinoma refractory/intolerant to platinum‐based chemotherapy: A multicenter observational retrospective study (WJOG13420G)

International Journal of Cancer, EarlyView.
What's New? Platinum‐based chemotherapy is the first‐line treatment for unresectable gastrointestinal neuroendocrine carcinoma (NEC). Which treatments are most effective following platinum‐based regimens remains unclear. In this study, the authors compared clinical outcomes between NEC patients who received second‐ or later‐line treatments either with ...
Yuki Matsubara, Toshiki Masuishi, Waki Hosoda, Hidekazu Hirano, Saori Mishima, Hiroyuki Takahashi, Tomoyuki Otsuka, Kenta Kawasaki, Takeshi Kawakami, Kazuhiro Yanagihara, Takaya Shimura, Masato Komoda, Kozue Murayama, Keiko Minashi, Yoshiyuki Yamamoto, Yudai Shinohara, Shinichi Nishina, Nobuyuki Musha, Kyoko Kato, Kentaro Kawakami, Katsunori Shinozaki, Kenji Tsuchihashi, Takayuki Ando, Yosuke Kito, Akitaka Makiyama, Seiichiro Mitani, Kaori Hino, Naoki Izawa, Isao Oze, Kei Muro   +29 more
wiley   +1 more source

Methylation‐based alcohol consumption scores as prognostic biomarkers in colorectal cancer: Insights from a population‐based cohort

International Journal of Cancer, EarlyView.
What's New? Alcohol's prognostic role in colorectal cancer remains uncertain, partly due to biases in self‐reported intake. This is the first study to evaluate blood DNA methylation‐based alcohol consumption scores as prognostic biomarkers in colorectal cancer.
Tanwei Yuan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge‐Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Bläker, Hermann Brenner, Michael Hoffmeister   +8 more
wiley   +1 more source

Primary Gallbladder and Rectal Neoplasms: Rare Synchronous Digestive Tumors

, 2016
Elias Makhoul, Yara Assaf
openalex   +1 more source

Is the incidence of early‐onset cancers increasing in the northeast of Italy? A 30‐year analysis of the regional cancer registration data by age, 1987–2019

International Journal of Cancer, EarlyView.
Whats New? This observational study of the incidence trends of malignancy by site, stratified by age group and sex, over three decades in a large northern Italian population reveals a heterogeneous landscape among younger adults (aged under 50). Invasive cutaneous melanoma in both sexes, testicular cancer and multiple myeloma in males, and breast ...
Alessandra Buja, Chiara Trevisiol, Andrea Miatton, Stefano Guzzinati, Emanuela Bovo, Simone Mocellin, Alberto Fantin, Massimo Rugge, Vincenzo Bronte, Manuel Zorzi   +9 more
wiley   +1 more source