Results 221 to 230 of about 533,732 (298)

Multicompartmental prolapse: A comparative study between clinical examination and ultrasound

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The accurate diagnosis of multicompartment pelvic organ prolapse (POP) is fundamental to surgical success. This study aims to compare the diagnostic performance of transperineal ultrasound against clinical examination (pelvic organ prolapse quantification, POP‐Q) for the detection of compartmental defects in patients with ...
José Antonio García‐Mejido, Olaya Salas‐Alvarez, Fernando Bugatto‐Gonzalez, Ana Fernández‐Palacín, Fernando Fernández‐Palacín, José Antonio Sainz‐Bueno   +5 more
wiley   +1 more source

Morphology of the midgut and hindgut and pollen-feeding ecology of Eulasia arctos anatolica (Reitter, 1903) (Coleoptera: Glaphyridae). [PDF]

BMC Zool
Ersoy DE, Özyurt Koçakoğlu N, Arslan H, Candan S.   +3 more
europepmc   +1 more source

mRNA Vaccination for Treating Allergy by Modulating Allergen‐Specific Immunity

iLABMED, EarlyView.
This News and Views article discusses the rationale for anti‐allergy vaccine development using a lipid nanoparticle‐mRNA platform. The authors provide additional evidence that supports the potential of using the mRNA approach to combat allergic diseases.
Kun Guo, Lijing Liu, Mingyun Shen, Karin Loré, Ang Lin   +4 more
wiley   +1 more source

Targeting DGKα/PA axis inhibits tumor immune evasion and augments sensitivity to immunotherapy in gastrointestinal cancers

iMeta, EarlyView.
Immune checkpoint inhibitors (ICIs) have shown promising antitumor efficacy in certain types of solid tumors. However, the efficacy of ICIs remains unsatisfactory owing to the dysregulation of signaling pathways in local tumor tissues. Here, we reveal that diacylglycerol kinase α (DGKα)‐derived phosphatidic acid (PA) directly binds to nuclear factor‐κB
Jie Chen, Siqi Liu, Ting Peng, Fenglong Wang, Yuheng Zhu, Jingyuan Pang, Qingnan Wu, Yan Wang, Qimin Zhan   +8 more
wiley   +1 more source

Region-specific Multi-Omics Modeling for Predicting Acute Radiation-Induced Proctitis in Cervical Cancer Radiotherapy: A Retrospective Analysis. [PDF]

Technol Cancer Res Treat
Xiao G, Quan K, Zeng M, Ye Y, Hong J, Liu Z, Wu H.   +6 more
europepmc   +1 more source

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

The impact of bladder and rectal dynamics on prostate and seminal vesicles intrafraction motion and deformation in radiotherapy. [PDF]

Phys Imaging Radiat Oncol
Lunardo F, Tan A, Baker L, Baines J, Squire T, Dowling JA, Azghadi MR, Gillman AG.   +7 more
europepmc   +1 more source

Chinese pan‐cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real‐world clinical sequencing cohort

Interdisciplinary Medicine, EarlyView.
We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li, Shun Wang, Guowei Zhao, Jiangtao Li, Xin Li, Bingning Wang, Yi Zhang, Mengfei Yao, Lei Guo, Jianming Ying, Wenbin Li   +10 more
wiley   +1 more source

The Gamboa-Hoil Point for Primary Perineal Closure During Total Pelvic Exenteration. [PDF]

Cureus
Gamboa-Hoil SI, Gamboa-Gutiérrez R, Medina-Campos A.   +2 more
europepmc   +1 more source

Intratumoral bacteria engineered for tumor therapy

Interdisciplinary Medicine, EarlyView.
This article comprehensively reviews engineered intratumoral bacteria used in tumor therapy. The concept development, characteristics, and engineering methods of intratumoral bacteria are summarized. The mechanisms and the translational significance by which engineered intratumoral bacteria interfere with tumor progression are discussed and highlighted.
Huajie Zhang, Zelin Chen, Zeyu Yao, Sishi Luo, Cheng Luo, Rui Yang, Hao Fu, Songyin Huang   +7 more
wiley   +1 more source