Results 101 to 110 of about 1,206,872 (317)
SurgeriesPilonidal sinus disease increasingly affects children and adolescents. While recurrence rates in adults are lower, with a minimum of 2% per year, and are essentially a function of the surgical approach over time, this is totally different in children ...
Christina Oetzmann von Sochaczewski +1 more
doaj +1 more source
, 2017 Backgroud: Increasing evidence suggests the involvement of chronic inflammation in the progression of prostate cancer, and prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase-2, catalyzes the rate-limiting steps of the pathway. We
Lee, Cheng-Hsueh;Pao, Jiunn-Bey;Lu, Te-Ling;Lee, Hong-Zin;Lee, Yung-Chin;Liu, Chia-Chu;Huang, Chao-Yuan;Lin, Victor C.;Yu, Chia-Cheng;Yin, Hsin-Ling;Huang, Shu-Pin;Bao, Bo-Ying +1 more
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
European Journal of Combinatorics, 2003 This paper is related to the graph isomorphism problem and deals with particular types of graph invariants called graph recurrence sequences. Let \(G\) be a graph of order \(n\) with adjacency matrix \(A\). Then each vector \(x_0\in \mathbb{R}^n\) determines a graph recurrence sequence \(\{x_i\}_{i=1}^n\) whose terms satisfy the recurrence \(x_{t+1}=A ...
Department of Mathematics, University of Florida, Gainesville, FL 32611, USA ( host institution ) +1 more
openaire +2 more sources
Talc pleurodesis for malignant pleural effusion: efficacy and factors predicting recurrence [PDF]
, 2014 Objectives: To identify potential factors predicting recurrence after talc pleurodesis for malignant pleural effusion. Methods: Retrospective study of two cohorts of consecutive patients undergoing surgery for malignant pleural effusion (T VATS/talc ...
Getzki ,T +8 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Pediatrics and Neonatology, 2010 To study the epidemiology of childhood intussusception and risk factors of recurrence and operation based on a nationwide data. Methods: Children with hospitalization due to intussusception (ICD9: 560.0) between 1998 and 2007 were identified from a ...
Solomon Chih-Cheng Chen +5 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source