Results 111 to 120 of about 1,784,395 (294)

Significant Pathologic Response Following Neoadjuvant Therapy and Curative Resection in Patients With Rectal Cancer: Surgical and Oncological Outcomes From a Retrospective Cohort Study

Cancer Reports
Aim This study evaluated surgical complication rates, recurrence‐free survival, overall survival (OS), and stoma status of patients with rectal cancer after significant pathologic response following neoadjuvant treatment and curative resection ...
Fatemeh Shahabi, Majid Ansari, Khadijeh Najafi Ghobadi, Abolfazl Ghahramani, Amiresmaeil Parandeh, Maryam Saberi‐Karimian, Ala Orafaie, Abbas Abdollahi   +7 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Impact of prophylactic central lymph node dissection on the complications and recurrence rates in papillary thyroid carcinoma—An AFCE (French‐speaking Association of Endocrine Surgery) multicentre study based on the EUROCRINE® national data

Cancer Reports
Background Prophylactic central neck dissection (pCND) remains controversial during the initial surgery for preoperative and intraoperative node‐negative (cN0) papillary thyroid carcinoma (PTC).
Nathalie Chereau, Niki Christou, Robert Caiazzo, Adrien Le Fouler, Jean Christophe Lifante, Laure Maillard, Eric Mirallie, Francois Pattou, Nicolas Bouviez, Nicolas Santucci, Laurent Brunaud, Fabrice Menegaux   +11 more
doaj   +1 more source

Biochemical properties of collagen metabolism in patients with recurrent genital prolapse [PDF]

Medičnì Perspektivi, 2013
Purpose – to determine the features of collagen metabolism state in women with recurrent genital prolapse at the stage of scheduled surgery and in postoperative period using prolene implants.
Banakhevich R.М.
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effects of perioperative anesthetics on the postoperative prognosis of patients undergoing surgery for cervical cancer

Frontiers in Pharmacology
Cervical cancer is a common malignancy among women, and tumor excision is the most common surgical intervention. Anesthetics used during surgery include general intravenous, volatile, local anesthetics, sedative and analgesic. Studies have shown that the
Linyan Deng, Linyan Deng, Linyan Deng, Tingting Wang, Tingting Wang, Tingting Wang, Qiaofeng Zhang, Qiaofeng Zhang, Qiaofeng Zhang, Shaofang Shu, Shaofang Shu, Shaofang Shu, Xiangdong Chen, Xiangdong Chen, Xiangdong Chen   +14 more
doaj   +1 more source

Prediction of bladder tumor relapse based on the risk factors and characteristics of the treatment [PDF]

Medičnì Perspektivi, 2015
Objectives. To investigate the possibility of predicting recurrence of bladder tumors based on the clinical and morphological features of the disease and preoperative intravesical instillation of probiotic Aerococcus viridans 167.
Molchanov R.N., Blyuss O.B.
doaj  

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Features of recurrence of varicose disease of the lower limb and its surgical correction

Амбулаторная хирургия
Despite the rapid development and rapid spread of minimally invasive techniques in the surgical treatment of chronic venous diseases in recent years, the relapse rate, taking into account the postoperative period, continues to remain high.
P. N. Myshentsev, S. E. Katorkin
doaj   +1 more source