Results 61 to 70 of about 717,209 (287)

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Airway epithelial cell-specific deletion of EGFR modulates mucoinflammatory features of cystic fibrosis-like lung disease in mice

Frontiers in Immunology
Mucoinflammatory lung disease in cystic fibrosis (CF) is characterized by airway surface liquid (ASL) layer dehydration and mucins hyperconcentration, which leads to airway obstruction, inflammation, bronchiectasis, and increased susceptibility to ...
Ishita Choudhary, Kshitiz Paudel, Rahul Kumar, Amit Sharma, Sonika Patial, Yogesh Saini   +5 more
doaj   +1 more source

A region on equine chromosome 13 is linked to recurrent airway obstruction in horses

, 2007
REASONS FOR STUDY: Equine recurrent airway obstruction (RAO) is probably dependent on a complex interaction of genetic and environmental factors and shares many characteristic features with human asthma.
Swinburne, J E, Burger, D, Gerber, V, Ramseyer, A, Jost, U, Blott, S, Dolf, G, Klukowska-Rötzler, J, Bugno, M   +8 more
core   +1 more source

Generation of Nasal Cell‐Derived Human Alveolar Organoids and Organoid‐Macrophage Assembloids for in Vitro Lung Modeling

Advanced Science, EarlyView.
This study demonstrates the generation of human alveolar organoids from nasal cells, which, when co‐cultured with monocyte‐derived macrophages, promotes maturation of both components and forms alveolar assembloids resembling native alveoli. These alveolar organoids and assembloids offer accessible, physiologically relevant in vitro systems for ...
Man Chun Chiu, Shuxin Zhang, Cun Li, Yifei Yu, Zhixin Wan, Jingjing Huang, Wei Xue, Ying Zhou, Xiaoxin Zhu, Qiaoshuai Lan, Jiali Wu, Zijun Zhao, Yuhong Liu, Xinjie Meng, Lin Huang, Hin Chu, Honglin Chen, Kelvin Kai‐Wang To, Kwok Yung Yuen, Jie Zhou   +19 more
wiley   +1 more source

Recurrent Respiratory Papillomatosis With Complete Response to Systemic Bevacizumab Therapy

Ear, Nose & Throat Journal
Recurrent respiratory papillomatosis is a condition caused by human papilloma virus, usually sub types 6 and 11. Papillomas are benign neoplasms that are most commonly found on the larynx and can be often associated with significant airway involvement ...
Daniel Gorelik BS, Amy Frantz MS, RN, CPNP, Jeffrey S. Dome MD, PhD, Brian K. Reilly MD   +3 more
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Air Pollution and Respiratory Permeability in Obstructive Sleep Apnea — A Review

Aerosol and Air Quality Research, 2020
Obstructive sleep apnea (OSA) is a common disorder characterized by recurrent episodes of nocturnal upper airway obstruction during sleep, which can seriously affect sleep quality and cause sleepiness during the daytime.
Nguyen Thanh Tung, Hoang Ba Dung, Tran Phan Chung Thuy, Huynh Nguyen Xuan Thao, Hsiao-Chi Chuang   +4 more
doaj   +1 more source

Comparison of genomic and proteomic data in recurrent airway obstruction affected horses using ingenuity pathway analysis [PDF]

, 2011
Background: Recurrent airway obstruction (RAO) is a severe chronic respiratory disease affecting horses worldwide, though mostly in the Northern hemisphere.
Couetil, Laurent L., Jiri Adamec, June E Swinburne, Feutz, Marybeth Miskovic, Racine, Julien, Adamec, Jiri, Laurent L Couetil, Riley, C Paige, Swinburne, June E, Marybeth Miskovic Feutz, C Paige Riley, Gerber, Vinzenz, Swinburne, June E., Miskovic Feutz, Marybeth, Julien Racine, Riley, C. Paige, Couetil, Laurent, Vinzenz Gerber   +17 more
core   +2 more sources

Pre‐Curved Everting Robots With Embedded Steering Intelligence Fabricated by CO2 Laser Welding

Advanced Intelligent Systems, EarlyView.
Design and experimental demonstration of a laser welded growing robot for anatomically guided navigation. The robot follows an aortic arch phantom entering the branchiocephalic branch through steering by design. The figure shows the physical phantom setup, CAD defined weld geometry and full robot eversion.
Brandon Saldarriaga, Panagiotis Kalozoumis, Panagiotis Vartholomeos, Carlo Seneci, Kawal Rhode, Christos Bergeles   +5 more
wiley   +1 more source

Second Scope, New Findings: Pediatric Stridor Is Not Always Due to Croup or Laryngomalacia: A Case Report

Clinical Practice and Cases in Emergency Medicine
Introduction: Infantile subglottic hemangioma is a rare and serious condition characterized by stridor, respiratory distress, and a barking cough. This condition poses a significant risk as it can lead to life-threatening airway obstruction. Case Report:
Summer Ghaith, Deborah Hsu, William Dixon   +2 more
doaj   +1 more source