Results 41 to 50 of about 347,214 (307)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Recurrent selection of popcorn composites UEMCO1 and UEM-CO2 based on selection indices [PDF]

, 2017
Selection indices were applied to data sets of 169 half-sib families of the popcorn composites UEM-Co1 and UEM-Co2 in four cycles of recurrent selection.
Amaral Junior, Antonio Teixeira do, Vieira, Rafael Augusto, Scapim, Carlos Alberto, Rocha, Renato da   +3 more
core   +3 more sources

Procedures for identification of superior progenies in successive generations of evaluation in common bean

Scientia Agricola
: When breeding the common bean in Brazil, the best progenies are chosen, normally, from solely the generation under analysis at the conclusion of the evaluation, without considering what occurred in the past.
Roxane do Carmo Lemos, Ângela de Fátima Barbosa Abreu, Magno Antonio Patto Ramalho   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Recurrent antitopographic inhibition mediates competitive stimulus selection in an attention network

, 2011
Topographically organized neurons represent multiple stimuli within complex visual scenes and compete for subsequent processing in higher visual centers. The underlying neural mechanisms of this process have long been elusive.
Harald Luksch, Ralf Wessel, Luksch, Harald, Dihui Lai, Brandt, Sebastian, Sebastian Brandt, Lai, Dihui, Wessel, Ralf   +7 more
core   +1 more source

Nutritional Security in Drylands: Fast-Track Intra-Population Genetic Improvement for Grain Iron and Zinc Densities in Pearl Millet

Frontiers in Nutrition, 2019
Considering the pervasive malnutrition caused by micronutrients, particularly those arising from the deficiencies of iron (Fe) and zinc (Zn), the primary focus of research in pearl millet is on biofortifying the crop with these two minerals. Pearl millet
Mahalingam Govindaraj, Kedar Nath Rai, Anand Kanatti, Aluri Sambasiva Rao, Harshad Shivade   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Divergent clonal selection dominates medulloblastoma at recurrence [PDF]

Nature, 2016
The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma with 'humanized' in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated ...
Morrissy AS, Garzia L, Shih DJH, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli FMG, Ramaswamy V, Lindsay PE, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, Li YS, Mayoh C, Thiessen N, Mercier E, Mungall KL, Ma Y, Tse K, Zeng T, Shumansky K, Roth AJL, Shah S, Farooq H, Kijima N, Holgado BL, Lee JJY, Matan-Lithwick S, Liu J, Mack SC, Manno A, Michealraj KA, Nor C, Peacock J, Qin L, Reimand J, Rolider A, Thompson YY, Wu XC, Pugh T, Ally A, Bilenky M, Butterfield YSN, Carlsen R, Cheng Y, Chuah E, Corbett RD, Dhalla N, He A, Lee D, Li HYI, Long W, Mayo M, Plettner P, Qian JQ, Schein JE, Tam A, Wong T, Birol I, Zhao YJ, Faria CC, Pimentel J, Nunes S, Shalaby T, Grotzer M, Pollack IF, Hamilton RL, Li XN, Bendel AE, Fults DW, Walter AW, Kumabe T, Tominaga T, Collins VP, Cho YJ, Hoffman C, Lyden D, Wisoff JH, Garvin JH, Stearns DS, Massimi L, Schuller U, Sterba J, Zitterbart K, Puget S, Ayrault O, Dunn SE, Tirapelli DPC, Carlotti CG, Wheeler H, Hallahan AR, Ingram W, MacDonald TJ, Olson JJ, Van Meir EG, Lee JY, Wang KC, Kim SK, Cho BK, Pietsch T, Fleischhack G, Tippelt S, Ra YS, Bailey S, Lindsey JC, Clifford SC, Eberhart CG, Cooper MK, Packer RJ, Massimino M, Garre ML, Bartels U, Tabori U, Hawkins CE, Dirks P, Bouffet E, Rutka JT, Wechsler-Reya RJ, Weiss WA, Collier LS, Dupuy AJ, Korshunov A, Jones DTW, Kool M, Northcott PA, Pfister SM, Largaespada DA, Mungall AJ, Moore RA, Jabado N, Bader GD, Jones SJM, Malkin D, Marra MA, Taylor MD   +137 more
openaire   +7 more sources

New strategy for evaluating grain cooking quality of progenies in dry bean breeding programs [PDF]

Crop Breeding and Applied Biotechnology, 2017
The methodology available for evaluating the cooking quality of dry beans is impractical for assessing a large number of progenies. The aims of this study were to propose a new strategy for evaluating cooking quality of grains and to estimate genetic and
Bruna Line Carvalho, Magno AntonioPatto Ramalho, Indalécio Cunha Vieira Júnior, Ângela de Fátima Barbosa Abreu   +3 more
doaj   +1 more source