Results 61 to 70 of about 347,214 (307)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma [PDF]

, 2003
BACKGROUND: We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with advanced ovarian cancer. The results are compared with that of a similar assay used
Pauline A Whitehouse, Federica Di Nicolantonio, Whitehouse, PA, Cree, IA, Bernard R Higgins, Di Nicolantonio Federica, Mercer Stuart J, Cree Ian A, Knight, LA, Higgins, BR, Osborne Richard, Kurbacher, CM, Kurbacher Christian M, Di Nicolantonio, Federica, Stuart J Mercer, Osborne, R, Richard Osborne, Alan Lamont, Whitehouse Pauline A, Louise A Knight, Sanjay Sharma, Di Nicolantonio, F, Neale Michael H, Andrew C Hindley, Hindley Andrew C, Sharma Sanjay, Knight Louise A, Lamont, A, Higgins Bernard R, Neale, MH, Ian A Cree, Hindley, AC, Mercer, SJ, Lamont Alan, Michael H Neale, Christian M Kurbacher, Sharma, S   +36 more
core   +1 more source

Selecting common bean breeding populations via mixed models

Bioscience Journal, 2018
Choosing breeding populations in a common bean (Phaseolus vulgaris L.) breeding program by recurrent selection is a crucial step, since it maximize the effort to find superior inbred lines.
Ramon Gonçalves de Paula, Igor Gonçalves de Paula, Ana Laura Nicomedes Carneiro, Felipe Vicentino Salvador, José Eustáquio de Souza Carneiro, Pedro Crescêncio Souza Careiro   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Seleção de progênies de meio-irmãos de milho para eficiência no uso de nitrogênio Selection of half-sib of maize for nitrogen use efficiency

Revista Ciência Agronômica, 2012
O trabalho teve por objetivo estimar os parâmetros e os ganhos genéticos na seleção de progênies de meio-irmãos para eficiência no uso de nitrogênio, por meio de seleção simultânea de caracteres.
Rafael Heinz, Leandro Henrique de Sousa Mota, Manoel Carlos Gonçalves, Antonio Luiz Viegas Neto, André Carlesso   +4 more
doaj   +1 more source

Recurrent Selection in the Domestic Fowl , ,

Poultry Science, 1970
Abstract RECURRENT selection in animal breeding refers to Hull’s (1945) method of selection for specific combining ability with a tester stock. Bell et al. (1952) pointed out that this breeding method was based on the performance of the crossbred progeny from an inbred tester line and a non-inbred or segregating population. Selection was based on the
L.D. Andrews, A.B. Stephenson
openaire   +1 more source

Recurrent Selection for Rubber Yield in Russian Dandelion [PDF]

Journal of the American Society for Horticultural Science, 2017
Russian dandelion [ Taraxacum kok-saghyz (TKS)] is a promising alternative to the Para rubber tree ( Hevea brasiliensis ) as a source of natural rubber; however, rubber yields must be improved for this undomesticated species to become a profitable new ...
Hodgson-Kratky, Katrina J. M., Stoffyn, Olivier M., Wolyn, David J.   +2 more
openaire   +4 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Implementation of rapid cycle recurrent genomic selection for forage yield in perennial ryegrass

Opportunities exist to accelerate genetic gain in forage breeding using genome-wide selection approaches. In this study, we evaluated rapid cycle recurrent genomic selection (GS) as a means of improving genetic gain for value of annual forage yield.
A. Konkolewska, P. Conaghan, S. Byrne, D. Milbourne, S.K. Arojju   +4 more
core   +1 more source