Results 61 to 70 of about 21,414,113 (306)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity
Neurobiology of DiseaseThe pathophysiological process of Alzheimer's disease (AD) is believed to begin many years before the formal diagnosis of AD dementia. This protracted preclinical phase offers a crucial window for potential therapeutic interventions, yet its ...
Giulio Bonifazi +7 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
DFT ispitivanje antioksidativne aktivnosti alizarina Red S
, 2016 Density functional theory calculations were performed to evaluate the antioxidant activity of alizarin red S molecule. The conformational behavior of molecule were analysed at the M06-2X/6-311++G(d,p) method.
Markovic, Z +3 more
core
Rapid Assessment of Relative Hemolysis Amidst Input Uncertainties in Laminar Flow
FluidsPredicting absolute values of hemolysis using the power law model to guide medical device design is hampered by uncertainties stemming from four sources of model inputs: incoming/upstream velocity profiles, blood viscosity models, power law hemolysis ...
Nasim Gholizadeh +3 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Compartiendo aprendizajes, el Proyecto RED SICTA
, 2010 Locutores: Susana Fevrier y Luis Diego Solórzano Entrevistados: Armando Ferrufino, Jesús Pérez, Mariano Valladares, Efraín García, Marcelo Núñez, Israel Gálvez.Hoy nos enlazamos con productores, técnicos y especialistas que desde distintos países de ...
Instituto Interamericano de Cooperación para la Agricultura (IICA) +8 more
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International Journal for Parasitology: Parasites and Wildlife, 2020 Sarcocysts of various Sarcocystis spp. are highly prevalent in wild sika deer, Cervus nippon yesoensis, in Hokkaido, Japan, and four species have been identified based on morphological and molecular characteristics: S. ovalis, S. pilosa, S. tarandi-like,
Takao Irie +5 more
doaj +1 more source
The toxic effects of alizarin red S on catalase at the molecular level
RSC Advances, 2019 Alizarin red S is confirmed to be toxic to catalase at molecular level attributing to the structural and functional changes of catalase.
Shimeng Hu +7 more
openaire +3 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source