Results 101 to 110 of about 1,821,043 (357)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Drugs for preventing red blood cell dehydration in people with sickle cell disease. [PDF]

, 2018
BACKGROUND: Sickle cell disease is an inherited disorder of hemoglobin, resulting in abnormal red blood cells. These are rigid and may block blood vessels leading to acute painful crises and other complications.
Ballas, Samir K., Nagalla, Srikanth
core   +1 more source

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

Molecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien, Marta E. Hjelmeland, Hege F. Berg, Rose M. Gold, Kathrine Woie, Lars A. Akslen, Ingfrid S. Haldorsen, Camilla Krakstad   +7 more
wiley   +1 more source

Research progress on the role of red blood cells in infectious diseases

Zhongguo shuxue zazhi
As the most abundant cells in blood, red blood cells have been gradually found to not only transport oxygen and carbon dioxide, but also participate in immune regulation in many ways.
Ling XIAO, Li TIAN
doaj   +1 more source

Fluorescence Exclusion: A Simple Method to Assess Projected Surface, Volume and Morphology of Red Blood Cells Stored in Blood Bank

Frontiers in Medicine, 2018
Red blood cells (RBC) ability to circulate is closely related to their surface area-to-volume ratio. A decrease in this ratio induces a decrease in RBC deformability that can lead to their retention and elimination in the spleen.
Camille Roussel, Camille Roussel, Camille Roussel, Camille Roussel, Camille Roussel, Sylvain Monnier, Michael Dussiot, Michael Dussiot, Elisabeth Farcy, Olivier Hermine, Olivier Hermine, Olivier Hermine, Olivier Hermine, Caroline Le Van Kim, Caroline Le Van Kim, Caroline Le Van Kim, Yves Colin, Yves Colin, Yves Colin, Matthieu Piel, Matthieu Piel, Pascal Amireault, Pascal Amireault, Pascal Amireault, Pascal Amireault, Pierre A. Buffet, Pierre A. Buffet, Pierre A. Buffet, Pierre A. Buffet, Pierre A. Buffet   +29 more
doaj   +1 more source

Cross-sectional focusing of red blood cells in a constricted microfluidic channel [PDF]

arXiv, 2019
Constrictions in blood vessels and microfluidic devices can dramatically change the spatial distribution of passing cells or particles and are commonly used in biomedical cell sorting applications. However, the three-dimensional nature of cell focusing in the channel cross-section remains poorly investigated.
arxiv  

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study [PDF]

, 2018
Background: Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms—many related to the structure or function of red blood cells—and risk for severe Plasmodium falciparum ...
Alexander, W Macharia, Anna, Jeffreys, Bancone, G., Benjamin, Tsofa, Carolyne, M Ndila, Christina, Hubbart, Dominic, P Kwiatkowski, Gavin, Band, Geraldine, Clarke, Gideon, Nyutu, Hughes, C., John, Ojal, Kate, Rowlands, Kathryn, Maitland, Kennedy, O Awuondo, Kevin, Marsh, Kirk, A Rockett, Malariagen, Consortium, Mangano, V., Margaret, Mackinnon, Modiano, David, Mohammed, Shebe, Neema, Mturi, Norbert, Peshu, Nuno, Sepúlveda, Silvia, Kariuki, Sophie, Uyoga, Taane, G Clark, Thomas, N Williams   +28 more
core   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

The impact of low erythrocyte density in human blood on the fitness and energetic reserves of the African malaria vector Anopheles gambiae [PDF]

, 2013
Background Anaemia is a common health problem in the developing world. This condition is characterized by a reduction in erythrocyte density, primarily from malnutrition and/or infectious diseases such as malaria.
A Dao, A De Loof, A Rivero, AN Clements, B Schiefer, BA Okech, C Garrett-Jones, C Stone, D Proven, DE Impoinvil, E Van Handel, E Van Handel, E Van Handel, EO Lyimo, F Aboagye-Antwi, F Aboagye-Antwi, H Briegel, H Briegel, H Briegel, H Briegel, H Hurd, H Hurd, H Manda, Heather M Ferguson, HM Ferguson, II Abdelrahim, JC Beier, JC Hogg, JH Oliveira, JK Nayar, JM Mukiibi, JN Shieh, JR Carey, KA Carlson, LA Baton, Lisa C Ranford-Cartwright, M Bukar, MJ Crawley, NR Van den Broek, P Hougaard, PFL Boreham, PJ Taylor, PW Price, R Carter, R Ross, RA Anderson, RS Nasci, S Noushin Emami, SC Stearns, T Flatt, TK Nkuo-Akenji, TL Daniel, VF Fairbanks, WA Foster, WA Maier   +54 more
core   +3 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source