Results 121 to 130 of about 2,373,679 (282)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Abnormal Angle-Dependent Multi-Channel Filtering in Photonic Crystals Containing Hyperbolic Metamaterials

open access: yesNanomaterials
Tunneling modes in all-dielectric one-dimensional photonic crystals can be utilized for multi-channel filtering. However, these tunneling modes generally blue shift upon increasing the incident angle. When hyperbolic metamaterials are introduced into one-
Mingyan Xie   +3 more
doaj   +1 more source

Red Shift: Procedural Shift-Reduce Parsing

open access: yes, 2017
Red Shift is a new design pattern for implementing parsers. The pattern draws ideas from traditional shift-reduce parsing as well as procedural PEG parsers. Red Shift parsers behaves like shift-reduce parsers, but eliminate ambiguity by always prioritizing reductions over shifts. To compensate the resulting lack of expressivity, reducers are not simple
Laurent, Nicolas   +1 more
openaire   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Structural Analysis of the Large Stokes Shift Red Fluorescent Protein tKeima

open access: yesMolecules
The Keima family comprises large Stokes shift fluorescent proteins that are useful for dual-color fluorescence cross-correlation spectroscopy and multicolor imaging.
Ki Hyun Nam, Yongbin Xu
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Sleep Disruption and Shift Work Associate with Increased Risk of Reproductive Endocrine Disorders: Evidence from UK Biobank and Mendelian Randomization

open access: yesInternational Journal of Women's Health
Hanke Zhang,* Ruyu Luo,* Yuqing Fang, Hongbo Wang, Yanhui Li* Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, People’s Republic ...
Zhang H, Luo R, Fang Y, Wang H, Li Y
doaj  

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