Results 121 to 130 of about 5,746,488 (258)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

High sensitive fast gamma radiation sensor based on Yb-doped optical fiber: offline and online detection

JPhys Photonics
Radiation science has a wide range of applications, from industrial uses and medical treatments to space research and national defense. Optical fiber technology offers a flexible and sensitive alternative solution for accurate radiation measurements in ...
Esra Kendir Tekgül, Şerafettin Yaltkaya, Timuçin Emre Tabaru, Bülend Ortaç   +3 more
doaj   +1 more source

Photon frequency variation in non-linear electro-magnetism

Physics Letters B
We set a generalised non-linear Lagrangian, encompassing Born-Infeld and Heisenberg-Euler theories among others. The Lagrangian reduces to the Maxwell Lagrangian at lowest order.
Alessandro D.A.M. Spallicci, Abedennour Dib, José A. Helayël-Neto   +2 more
doaj   +1 more source

Mean reaction time (Standard deviation) for the Vertical-shift-object and Non-vertical-shift-object in the Spatial recall task and the Identity Task across four experiments.

, 2016
Mean reaction time (Standard deviation) for the Vertical-shift-object and Non-vertical-shift-object in the Spatial recall task and the Identity Task across four experiments.
David Uttal (3190695), Lei Yuan (713591), Steven Franconeri (3190698)   +2 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Bright red-emitting pyrene derivatives with a large Stokes shift for nucleus staining

, 2017
A red-emitting probe with a large Stokes shift (Δλ≈ 130 nm) exhibits great selectivity and sensitivity for cell nucleus imaging.
Kaveesha J. Wijesinghe, Robert V. Stahelin, Chathura S. Abeywickrama, Yi Pang   +3 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Variations of constants and red-shift in 6D cosmology

, 1996
On the basis of the general class of solutions of 6D vacuum Einstein equations and using well-known results of the 6D geometric model of electroweak and gravitational interactions, the variations of fundamental physical constants and their influence on ...
Alvarez, A.P., Vladimirov Yu.S.
core   +1 more source

A general strategy to red-shift green fluorescent protein-based biosensors. [PDF]

Nat Chem Biol, 2020
Zhang S, Ai HW.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source