Results 1 to 10 of about 192,013 (161)
Redox regulation by glutathione needs enzymes [PDF]
Frontiers in Pharmacology, 2014 The GSH/GSSG redox potential has become a fashionable electrochemical parameter believed to be a major driving force of redox reactions regulating biological events (Schafer and Buettner, 2001; Jones, 2006; Blanco et al., 2007; Chaiswing et al., 2012). Here, we will challenge this concept, because we consider it an untenable simplification that ignores
Carsten eBerndt +3 more
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Redox Enzymes in Tethered Membranes [PDF]
Journal of the American Chemical Society, 2006 An electrode surface is presented that enables the characterization of redox-active membrane enzymes in a native-like environment. An ubiquinol oxidase from Escherichia coli, cytochrome bo(3) (cbo(3)), has been co-immobilized into tethered bilayer lipid membranes (tBLMs). The tBLM is formed on gold surfaces functionalized with cholesterol tethers which
Lars Jeuken +2 more
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Redox Regulation of Cysteine-Dependent Enzymes in Neurodegeneration [PDF]
International Journal of Cell Biology, 2012 Evidence of increased oxidative stress has been found in various neurodegenerative diseases and conditions. While it is unclear whether oxidative stress is a cause or effect, protein, lipid, and DNA have all been found to be susceptible to oxidant ...
Rodney P. Guttmann, Tamara J. Powell
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The Potential Roles of Redox Enzymes in Alzheimer’s Disease: Focus on Thioredoxin [PDF]
ASN Neuro, 2021 Guangtao Xu, Jinjing Jia, Xiansi Zeng
exaly +2 more sources
Novel Reversible Inhibitors of Xanthine Oxidase Targeting the Active Site of the Enzyme
Antioxidants, 2023 Xanthine oxidase (XO) is a flavoprotein catalysing the oxidation of hypoxanthine to xanthine and then to uric acid, while simultaneously producing reactive oxygen species.
Rosario Rullo +6 more
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Enzyme based amperometric wide field biosensors: Is single‐molecule detection possible?
Electrochemical Science Advances, 2023 This review discloses the technological advances involving enzyme‐based amperometric biosensors engaging challenging limits of detection as low as a single molecule. At first, we summarise the most recent findings concerning electrode modification toward
Angelo Tricase +8 more
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Cytochrome bd as Antioxidant Redox Enzyme
Molecular Biology, 2023 Abstract One of the main functions of enzyme complexes that constitute electron transport (respiratory) chains of organisms is to maintain cellular redox homeostasis by oxidizing reducing equivalents, NADH and quinol.
Borisov Vitaliy +2 more
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ROS Defense Systems and Terminal Oxidases in Bacteria
Antioxidants, 2021 Reactive oxygen species (ROS) comprise the superoxide anion (O2•−), hydrogen peroxide (H2O2), hydroxyl radical (•OH), and singlet oxygen (1O2). ROS can damage a variety of macromolecules, including DNA, RNA, proteins, and lipids, and compromise cell ...
Vitaliy B. Borisov +3 more
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Regulation of dual oxidase hydrogen peroxide synthesis results in an epithelial respiratory burst
Redox Biology, 2021 Redox status is a central determinant of cellular activities and redox imbalance is correlated with numerous diseases. NADPH oxidase activity results in formation of H2O2, that, in turn, sets cellular redox status, a key regulator of cellular homeostasis
Gregory E. Conner
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Computational modeling of redox enzymes
FEBS Letters, 2022 A computational methodology is briefly described, which appears to be able to accurately describe the mechanisms of redox active enzymes. The method is built on hybrid density functional theory where the inclusion of a fraction of exact exchange is critical. Two examples of where the methodology has been applied are described.
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