Results 151 to 160 of about 171,869 (285)

Expression characteristics of dual‐specificity phosphatase 2 and hypoxia‐inducible factor‐1α in acute kidney injury and preliminary study of the effect of dual‐specificity phosphatase 2 on HK‐2 cells

Experimental Physiology, EarlyView.
ABSTRACT Acute kidney injury (AKI) is a global health problem with significant long‐term harm if the prognosis is poor. Dual‐specificity phosphatase 2 (DUSP2) is involved in key regulatory pathways in several disease processes, but its function in renal pathophysiology is unclear.
Xueqian Chu, Songmin Xue, Lanyan Lin, Xuan Huang, Sisi Chen, Wulaer Adeli, Zulibiya Tuohetiyaer, Suhua Li, Chen Lu   +8 more
wiley   +1 more source

Modeling the Impacts of Self‐Sufficiency Scenarios on Norwegian National Nutrient Supply

Climate Resilience and Sustainability, Volume 5, Issue 1, June 2026.
Food and nutrient flows through national food systems have important implications for national self‐sufficiency. Here, we examine food and nutrient flows through the Norwegian food system currently and under various possible scenarios. ABSTRACT As a part of the Norwegian strategy to meet the commitments they have made through international climate ...
Raquel Lozano, Nick William Smith, Katrine Lekang, Warren Charles McNabb   +3 more
wiley   +1 more source

Reduced Folate Carrier and Folylpolyglutamate Synthetase, but not Thymidylate Synthase Predict Survival in Pemetrexed-Treated Patients Suffering from Malignant Pleural Mesothelioma

Journal of Thoracic Oncology, 2013
F. Mairinger, C. Vollbrecht, I. Halbwedl, Martina Hatz, E. Stacher, C. Gülly, F. Quehenberger, S. Stephan-Falkenau, J. Kollmeier, A. Roth, T. Mairinger, H. Popper   +11 more
semanticscholar   +1 more source

Metabolic‐immune interactions in gastric cancer T cells: A single‐cell atlas for prognostic biomarker identification

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Metabolic alterations and immune dysfunction within the gastric tumor microenvironment critically drive gastric cancer (GC) progression and therapeutic resistance. Although single‐cell RNA sequencing (scRNA‐seq) has unveiled cellular heterogeneity in GC, the metabolic landscapes of tumor cells and their interplay with immune components remain ...
Junjun Liu, Rui Zhao, Guodong Yao, Zhao Liu, Runze Shi, Jingshu Geng, Guanying Liang, Kexin Chen   +7 more
wiley   +1 more source

Reprogramming SREBP1‐dependent lipogenesis and inflammation in high‐risk breast with licochalcone A: A novel path to cancer prevention

International Journal of Cancer, Volume 158, Issue 7, Page 1927-1940, 1 April 2026.
What's new? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Atieh Hajirahimkhan, Elizabeth T. Bartom, Carolina H. Chung, Xingyu Guo, Kyli Berkley, Seyyedmohsen Hosseinibarkooie, Zahra Assadi, Shao Huan Samuel Weng, Raymond Moellering, Oukseub Lee, Ruohui Chen, Wonhwa Cho, Sriram Chandrasekaran, Susan E. Clare, Seema A. Khan   +14 more
wiley   +1 more source

SLC46A1 deficiency-mediated folate restriction suppresses colorectal cancer progression through epigenetic-transcriptional reprogramming. [PDF]

Cell Death Dis
Zhou Y, Liu Y, Liu Y, Che C, Zhao Y, Yu J, Li X, Li A, Chen S, Wang H, Zhou M, Liu D, He W, Wang Z, Han H, Wang X, Lu Y, Wu K, Zhao X.   +18 more
europepmc   +1 more source

Lactuca sativa L. losses and wastes as a source of biobased ingredients

Journal of the Science of Food and Agriculture, Volume 106, Issue 6, Page 3577-3591, April 2026.
Abstract BACKGROUND The growing global population and increasing consumer focus on healthy eating challenge the agricultural sector to ensure both sustainable food production and safety. Lettuce (Lactuca sativa Mill.), the most cultivated leafy vegetable worldwide, can lose up to 40% of its weight during processing.
Joana PB Rodrigues, Tayse FF da Silveira, Daniele B Rodrigues, Laura Domínguez, Patricia Morales, Tânia CSP Pires, Maria Beatriz PP Oliveira, Ângela Fernandes, Lillian Barros   +8 more
wiley   +1 more source

Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier.

Journal of Medicinal Chemistry, 2012
Lei Wang, Christina Cherian, Sita Kugel Desmoulin, Shermaine Mitchell-Ryan, Z. Hou, L. Matherly, A. Gangjee   +6 more
semanticscholar   +1 more source

Extracellular and Membrane Protein: Structure, Biological Functions, Diseases, and an Emerging Modality for Drug Discovery

MedComm, Volume 7, Issue 4, April 2026.
Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Mengqing Zhao, Wenhao Yin, Jianjian Han, Huimin Wang, Zheng Liu, Lilong Liu, Wuxiang Mao   +6 more
wiley   +1 more source

The Double-Edged Nature of Methyl Donors in Cancer Development from Prevention to Progression. [PDF]

Int J Mol Sci
Pan D, Wang S, Sun G.
europepmc   +1 more source