Results 131 to 140 of about 4,058,802 (278)

Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier. [PDF]

Bioorg Med Chem, 2020
Golani LK, Islam F, O'Connor C, Dekhne AS, Hou Z, Matherly LH, Gangjee A.   +6 more
europepmc   +1 more source

Differential expression of folate receptor α and reduced folate carrier and effect of folate in ovarian cancer

, 2008
Ovarian cancer is a common gynecological cancer world-wide and contributes to the highest mortality despite of advances in treatment modalities. There is increasing evidence that diet is a crucial factor in the development and progression of various ...
Siu, KY, Kong, SH, Chan, HY, Ngan, HYS, Cheung, ANY, Chan, KYQ   +5 more
core  

The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells

, 2005
Transport of folates and antifolates in both hepatocytes and Huh7 human hepatoma cells is characterized by a low-pH optimum. Studies were undertaken to determine the extent to which this transport activity is mediated by the reduced folate carrier (RFC ...
Zhao, Rongbao, Hanscom, Marie, Goldman, I. David   +2 more
core   +1 more source

Protein Glutamylation: From Cytoskeleton to Signaling

Med Research, EarlyView.
Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen, Yi Yuan, Qingquan Yu, Xinyue Wang, Hui Wang   +4 more
wiley   +1 more source

Folate metabolic pathway.

, 2018
Depiction of folate uptake and reduction, transmethylation, and transulfuration pathways. Genes in the shaded circles were analyzed for single nucleotide polymorphisms.
Zhongxue Chen (137919), Shirisha Chittiboyina (2393389), Barbara A. Hocevar (539956), Lisa M. Kamendulis (306718), E. Gabriela Chiorean (539963)   +4 more
core   +1 more source

Toxoplasma gondii Infection After Kidney Transplantation: A Case Report and Literature Review

Organ Medicine, EarlyView.
Toxoplasma gondii infection after kidney transplantation is rare and presents with nonspecific clinical manifestations; however, the associated mortality rate is high. We discuss the relevant literature, clinical manifestations, therapeutic regimens, and prognoses of post‐transplantation toxoplasmosis.
Peng Zhang, Xingqiang Lai, Rongxin Chen, Li Li, Jiali Fang, Guanghui Li, Junjie Ma, Luhao Liu, Zheng Chen   +8 more
wiley   +1 more source

A new physiological medium uncovers biochemical and cellular alterations in Lesch-Nyhan disease fibroblasts

Molecular Medicine
Background Lesch-Nyhan disease (LND) is a severe neurological disorder caused by the genetic deficiency of hypoxanthine–guanine phosphoribosyltransferase (HGprt), an enzyme involved in the salvage synthesis of purines.
Paula Escudero-Ferruz, Neus Ontiveros, Claudia Cano-Estrada, Diane J. Sutcliffe, H. A. Jinnah, Rosa J. Torres, José M. López   +6 more
doaj   +1 more source

The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity

Frontiers in Pharmacology
BackgroundL-Leucovorin (l-LV; 5-formyltetrahydrofolate, folinic acid) is a precursor for 5,10-methylenetetrahydrofolate (5,10-CH2-THF), which is important for the potentiation of the antitumor activity of 5-fluorouracil (5FU).
Godefridus J. Peters, Godefridus J. Peters, Ietje Kathmann, Elisa Giovannetti, Elisa Giovannetti, Kees Smid, Yehuda G. Assaraf, Gerrit Jansen   +7 more
doaj   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities

, 2001
Intestinal absorption of folates has been characterized as a facilitative process with a low pH optimum. Studies with intestinal epithelial cells have suggested that this activity is mediated by the reduced folate carrier (RFC1). In this paper, we report
Esteban E. Sierra, Rongbao Zhao, Arun Rajgopal, I. David Goldman   +3 more
core   +1 more source