Results 151 to 160 of about 4,058,802 (278)

Multifunctional Nanoreactor Based on Catalyst Surface Engineering Combines pH‐Adaptive Catalysis With Tumor Microenvironment Modulation for Synergistic Chemodynamic‐Chemotherapy

Small, EarlyView.
A folate‐targeted Fe2O3@MoS2‐Pt/FA nanoreactor creates a localized acidic catalytic interface while simultaneously elevating intracellular H2O2 and consuming GSH. This dual regulation of reaction conditions and substrate availability markedly enhances Fenton‐driven chemodynamic therapy and synergistic chemotherapy for efficient tumor eradication ...
Yuchen Liu, Shan Lin, Pengyuan Song, Xianan Li, Jingwen Wang, Yang Zhang, Mingli Cai, Kang Fu, Ziyue Xu, Qianqian Zhao, Long Zhang, Jie Shen, Shibo Wang, Xiangdong Kong, Pu Chen   +14 more
wiley   +1 more source

Structure and Regulation of the Murine Reduced Folate Carrier Gene [PDF]

Journal of Biological Chemistry, 2005
Mingjun Liu, Yubin Ge, Diane C. Cabelof, Amro Aboukameel, Ahmad R. Heydari, Ramzi Mohammad, Larry H. Matherly   +6 more
openaire   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

Smart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source

Engineering metal‐organic framework‐based smart porous nanoplatforms for targeted therapy and theranostic applications

Smart Molecules, EarlyView.
MOFs offer high porosity and tunability for biomedical applications, especially in cancer therapy via ROS generation and targeted delivery. Though toxicity, stability, and scalability remain key clinical challenges. Drug loading in MOFs exceeds 60%–70% with controlled release behavior.
Jagabandhu Bag, Subhasis Banerjee, Sabyasachi Banerjee, Sourav De, S. K. Ashok Kumar, Yan‐Jye Shyong, Subhankar Mukhopadhyay   +6 more
wiley   +1 more source

Therapeutic efficiency of folated poly(ethylene glycol)-chitosan-graft-polyethylenimine-Pdcd4 complexes in H-ras12V mice with liver cancer

International Journal of Nanomedicine, 2013
You-Kyoung Kim,1 Arash Minai-Tehrani,2 Jae-Ho Lee,2 Chong-Su Cho,3 Myung-Haing Cho,2–6 Hu-Lin Jiang1 1State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, People’s Republic of China;
Kim YK, Minai-Tehrani A, Lee JH, Cho CS, Cho MH, Jiang HL   +5 more
doaj  

Engineering ApoE‐Mimetic HDL‐Like Nanoparticles for Glioblastoma‐Targeted Theranostics

Small Methods, EarlyView.
An ApoE‐mimetic peptide enables the stable formation of sub‐30 nm HDL‐like nanoparticles (ApoEm‐PLP) that simultaneously engage multiple lipoprotein receptors. This multivalent receptor interaction facilitates the transport of ApoEm‐PLP into brain and enhances targeted delivery of ApoEm‐PLP to glioblastoma, resulting in uniform intratumoral porphyrin ...
Hanyi Weng, Rick Wentao Cui, Ling Xi Gong, Ashley Qian, Lili Ding, Nahyun Kwon, Yiming Yang, Yulin Mo, Tiffany Ho, Madeline K. Brown, Maneesha Amrita Rajora, Juan Chen, Gang Zheng   +12 more
wiley   +1 more source

Neonatal and Child Growth Monitoring: A Renewed Call for Uptake and Application of International Growth Standards

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective The Guidance for International Growth Standards (GIGS) project aims to improve and promote appropriate application of international growth standards across clinical, research and public health settings. Design A guidance document providing historical and conceptual context to support the appropriate application of international ...
Eric O. Ohuma, Bancy Ngatia, Simon Parker, Sara Strout, Linda Vesel   +4 more
wiley   +1 more source

First‐Trimester Maternal Gut Microbiome and Small Vulnerable Newborns: A Prospective Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objectives To investigate the relationship between the first trimester gut microbiome and small vulnerable newborns (SVN). Setting Rural low‐ and middle‐income country: Bangladesh. Population 213 women were enrolled during the first trimester of pregnancy as part of the NICHD Global Network for Women's and Children's Health registry ...
Rachel McMillan, Rebecca M. Dria, G. Brett Moreau, Jennie Z. Ma, Md. Shahjahan Siraj, Md. Mostofa Shakil, Sk. Masum Billah, William A. Petri Jr, Rashidul Haque, Gregory R. Madden   +9 more
wiley   +1 more source