Results 91 to 100 of about 538,127 (242)
Animal Models and Experimental Medicine, EarlyView.The antioxidant efficacy of Colocasia esculenta flower’s methanolic extract was assessed using 2,2′‐azino‐bis‐(3‐ethylbenzothiazoline‐6‐sulfonic) (ABTS) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) scavenging assay. The hepatoprotective effect was investigated by assessing liver injury indicators (amino transferase [ALT], aspartate amino transferase [AST],
Mahathir Mohammad +9 more
wiley +1 more source
キイロショウジョウバエ由来のチオレドキシン還元酵素のC未端テトラペプチド配列は、ヒト肺由来のチオレドキシン還元酵素では酸化還元活性を示さない [PDF]
, 2007 The isozymes of mammalian thioredoxin reductase (TrxR) contain the penultimate selenocysteineresidue (SeCys) in the redox-active C-terminal tetrapeptide, -Gly-Cys-SeCys-Gly (end). Amutant form of the mammalian enzyme TrxR-X498C in which SeCys is replaced
Inagaki, Kenji +3 more
core
Annals of Neurology, EarlyView.Objectives Rapid advances in transcriptomics have driven efforts to identify deregulated pathways in multiple sclerosis (MS) tissues, though many detected differentially expressed genes are likely false positives, with only a small fraction reflecting actual pathological events. Robust, integrative methods are essential for accurately understanding the
Gianmarco Abbadessa +11 more
wiley +1 more source
Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11[beta]-hydroxysteroid dehydrogenase 1 [PDF]
, 2008 Intracellular glucocorticoid reactivation is catalyzed by 11[beta]-hydroxysteroid dehydrogenase 1 (11[beta]-HSD1), which functions predominantly as a reductase in cells expressing hexose-6-phosphate dehydrogenase (H6PDH).
Alex Odermatt +4 more
core +1 more source
Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies
Annals of Neurology, EarlyView.Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel +10 more
wiley +1 more source
Angewandte Chemie International Edition, EarlyView.Natural combinatorics: Evolutionary mixing and matching of three cyanobacterial biosynthetic gene clusters resulted in the emergence of minutumamides, a novel family of peptide‐polyketide hybrids. Retro‐evolutionary analysis led to the discovery of nostopeptolide KVJ3, an evolutionary ancestor that links nostopeptolide and minutumamide biosynthesis and
Keishi Ishida +6 more
wiley +1 more source
Photo‐controlled Release of Urea Enables the Detection of Urea‐Urease Intermediates by cryo‐FTIR
Angewandte Chemie International Edition, Accepted Article.Caged compounds are a valuable tool to photocontrol the release of enzymatic substrates in a reaction. For example, caged urea molecules were proposed to control urea delivery to urease reactions and aid the determination of the catalytic mechanism of this enzyme.
Caterina Netto +7 more
wiley +1 more source
Angewandte Chemie International Edition, Accepted Article.Malleicyprol, a virulence factor of notorious animal and human pathogens of the Burkholderia pseudomallei (BP) group, features a molecular cyclopropanol warhead linked to a reactive butenolide core. Biosynthetic considerations suggested that this heterocycle was formed by the merger of two individual polyketide chains, but the precise mechanism has ...
Jonas Fiedler +5 more
wiley +1 more source
Angewandte Chemie International Edition, Accepted Article.Luminescent emitters based on lanthanide ions are of ubiquitous importance in the biological sciences, but typically need sensitisation from a covalently attached adjacent chromophore – an “antenna” – to have suitable emission intensities. Here we show that the mechanical bond can be used to connect the antenna to the emitter, providing unique dynamic ...
Anja Ramström +5 more
wiley +1 more source
Therapeutic Considerations Related to Finasteride Administration in Male Androgenic Alopecia and Benign Prostatic Hyperplasia [PDF]
, 2017 Finasteride has been used extensively until now as a relative efficient therapeutic option for male androgenic alopecia and benign prostatic hyperplasia.
Baconi, Daniela L +10 more
core +1 more source