Results 51 to 60 of about 83,848 (260)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

An Integrative Model of Mathematical Well-Being and Anxiety Reduction (I-WARM): Evidence from Teachers’ and Students’ Perspectives

open access: yesJurnal Kependidikan
This study aims to develop an Integrative Model of Mathematical Well-Being and Anxiety Reduction (I-WARM) based on the perspectives of secondary school teachers and students in Kupang City, Indonesia.
Maria Martini Aba   +3 more
doaj   +1 more source

Peningkatan Pemahaman Konsep Akar dan Perpangkatan dengan Model Pembelajaran Take and Give di Kelas V SDN Bendogerit 2 Kota Blitar

open access: yesEdukasia, 2021
Mathematics learning basically has abstract characteristics, as well as tiered concepts and principles. This causes many students to find it difficult to learn mathematics. The success of learning mathematics in elementary schools is shown by the mastery
Lina Krisnawati
doaj  

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

De l’événement au problème. Archéologie d’un paradigme mathématique [PDF]

open access: yesLa Deleuziana, 2020
The article deals with the presence in Deleuze of an image of mathematical thought centered on the idea of problem. This vision of mathematics, which Emile Bréhier’s studies trace back to the Stoic and Neoplatonic philosophies, feeds romantic thought as ...
Andrea
doaj  

Mathematical Theory Exploration in Theorema: Reduction Rings [PDF]

open access: yes, 2016
submitted to CICM 2015 (Conference on Intelligent Computer Mathematics)
openaire   +2 more sources

Reduction of Off‐Flavor Generation in Soybean Homogenates: A Mathematical Model [PDF]

open access: yesJournal of Food Science, 2010
Abstract:  The generation of off‐flavors in soybean homogenates such as n‐hexanal via the lipoxygenase (LOX) pathway can be a problem in the processed food industry. Previous studies have examined the effect of using soybean varieties missing one or more of the 3 LOX isozymes on n‐hexanal generation.
Mellor, Nathan   +3 more
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

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