Results 111 to 120 of about 776,097 (338)

Managing Complexity in Socio-Technical Systems by Mimicking Emergent Simplicities in Nature: A Brief Communication

open access: yesBiomimetics
In the context of socio-technical systems, traditional engineering approaches are inadequate, calling for a fundamental change in perspective. A different approach encourages viewing socio-technical systems as complex living entities rather than through ...
Andrea Falegnami   +3 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Philosophical Puzzles Evade Empirical Evidence: Some Thoughts and Clarifications Regarding the Relation Between Brain Sciences and Philosophy of Mind [PDF]

open access: yes, 2017
This chapter analyzes the relation between brain sciences and philosophy of mind, in order to clarify in what ways philosophy can contribute to neuroscience and neuroscience can contribute to philosophy.
Sarıhan, Işık
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Extension, Variability, and Normativity: Deniz Peters on Musical Experience

open access: yesEmpirical Musicology Review, 2015
In his essay, "Musical Empathy, Emotional Co-Constitution, and the 'Musical Other,'" Deniz Peters aims to present a non-reductive account of musical empathy in musical experience that takes seriously the contributions of bodily experience through what he
Philip Alperson
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

"In Defense of Pure Reason: A Rationalist Account of A Priori Justification" by Laurence BonJour [PDF]

open access: yes, 2003
Laurence BonJour divides approaches to a priori justification into three kinds. Quine’s radical empiricism denies the existence of any special category of a priori justification; moderate empiricism attempts to explain a priori ...
Crane, Tim
core  

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