Results 51 to 60 of about 15,211 (294)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Applied Sciences, 2020 Hyper-redundant continuum manipulators present dexterous kinematic skills in complicated tasks and demonstrate promising potential in underground exploration, intra-cavity inspection, surgery, etc.
Long Qin +4 more
doaj +1 more source
Spherical Wrist Manipulator Local Planner for Redundant Tasks in Collaborative Environments
Sensors, 2023 Standard industrial robotic manipulators use well-established high performing technologies. However, such manipulators do not guarantee a safe Human–Robot Interaction (HRI), limiting their usage in industrial and medical applications. This paper proposes
Marcello Chiurazzi +4 more
doaj +1 more source
Robot's hand and expansions in non-integer bases
, 2014 We study a robot hand model in the framework of the theory of expansions in non-integer bases. We investigate the reachable workspace and we study some configurations enjoying form closure properties.Comment: 22 pages, 10 ...
Lai, Anna Chiara, Loreti, Paola
core +5 more sources
Optimal mapping of joint faults into healthy joint velocity space for fault-tolerant redundant manipulators [PDF]
, 2011 redundant ...
Abdi +12 more
core +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Using Momentum Conservation to Control Kinematically Redundant Manipulators [PDF]
Modeling, Identification and Control, 1991 A control scheme for the coordination of motion in a macro-micro manipulator system is presented. The motion of the end-effector is decoupled from the rest of the system using resolved acceleration control, while a slow, gross positioning is used for the
Jan R. Sagli, Olav Egeland
doaj +1 more source
Dynamic Modeling and Simulation of a Rotating Single Link Flexible Robotic Manipulator Subject to Quick Stops [PDF]
, 2014 Single link robotic manipulators are extensively used in industry and research operations. The main design requirement of such manipulators is to minimize link dynamic deflection and its active end vibrations, and obtain high position accuracy during its
Dupac, Mihai, Noroozi, Siamak
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source