Results 31 to 40 of about 1,578 (257)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Continuous Genetic Algorithms for Collision-Free Cartesian Path Planning of Robot Manipulators

International Journal of Advanced Robotic Systems, 2011
A novel continuous genetic algorithm (CGA) along with distance algorithm for solving collisions-free path planning problem for robot manipulators is presented in this paper.
Za'er S. Abo-Hammour, Othman MK. Alsmadi, Sofian I. Bataineh, Muhannad A. Al-Omari, Nafee' Affach   +4 more
doaj   +2 more sources

Planning Fail-Safe Trajectories for Space Robotic Arms

Frontiers in Robotics and AI, 2021
A frequent concern for robot manipulators deployed in dangerous and hazardous environments for humans is the reliability of task executions in the event of a joint failure.
Oliver Porges, Daniel Leidner, Máximo A. Roa   +2 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Refined Self-Motion Scheme With Zero Initial Velocities and Time-Varying Physical Limits via Zhang Neurodynamics Equivalency

Frontiers in Neurorobotics, 2022
By considering the different-level time-varying physical limits in joint space, a refined self-motion control scheme via Zhang neurodynamics equivalency (SMCSvZ) of redundant robot manipulators is proposed, analyzed, and investigated in this manuscript ...
Zanyu Tang, Zanyu Tang, Zanyu Tang, Yunong Zhang, Yunong Zhang   +4 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Multipoint Variable parameter compliant control of redundant manipulator based on the equivalent twin model of flexible contact dynamics

International Journal of Advanced Robotic Systems
To elucidate the dynamic coupling mechanism involved in multipoint/arbitrary point contact during human–robot interactions with redundant manipulators, we introduce a compliant control strategy that adapts to variable parameters.
Genliang Xiong, Lan Ye, Xiaoqing Zhang, Yanfeng Gao, Zhang Hua, Yang Dapeng, Chao Yu, Qirong Tang   +7 more
doaj   +1 more source

Noise-Suppressing Newton Algorithm for Kinematic Control of Robots

IEEE Access
In this paper, armed with the integral control method, a new noise-suppressing Newton (NSN) algorithm is proposed for the redundancy resolution of redundant robot manipulators efficiently.
Xiuchun Xiao, Lin Wei, Dongyang Fu, Jingwen Yan, Huan Wang   +4 more
doaj   +1 more source

Numerical Quantification of Controllability in the Null Space for Redundant Manipulators

Applied Sciences, 2021
Redundant motion, which is possible when robotic manipulators are over-actuated, can be used to control robot arms for a wide range of tasks. One of the best known methods for controlling redundancy is the null space projection, which assigns a priority ...
Seonwoo Kim, Seongseop Yun, Dongjun Shin
doaj   +1 more source