Results 171 to 180 of about 5,500,427 (306)

A pseudochromosomal reference genome of the golden jackal, Canis aureus. [PDF]

J Hered
Winter S, Meißner R, Prost S, Greve C, Gerheim C, Arakelyan M, Aghayan SA, Ghazaryan A, Hatlauf J, Burger PA.   +9 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Complex subtelomeric architectures in a complete rhesus macaque reference genome. [PDF]

Cell
Zhang S, Xu N, Lu Y, Nie Y, Li Z, de Gennaro L, La Torraca A, Fu L, Zhang Z, Chen J, Ma K, Yang X, Zhang J, Schmitz MT, Antonacci F, Bakken TE, Ventura M, Phillippy AM, Sun Q, Mao Y.   +19 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Heard it through the grapevine: a phased reference genome for the polyploid Kyoho grape. [PDF]

Plant Physiol
Thomas WJW.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A telomere-to-telomere reference genome for Stemona tuberosa. [PDF]

Sci Data
Wei X, Tang D, Peng Y, Huang B, Zhu Y, Liang Z, Hu Y.   +6 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

A chromosome-level reference genome for the colonial marine hydrozoan Podocoryna americana. [PDF]

G3 (Bethesda)
Chang ES, Connelly MT, Travert M, Barreira SN, Rivera AM, Katzer AM, Yu R, Cartwright P, Baxevanis AD.   +8 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source