Results 81 to 90 of about 5,571,829 (332)

Analyzing AbrB-Knockout Effects through Genome and Transcriptome Sequencing of Bacillus licheniformis DW2

open access: yesFrontiers in Microbiology, 2018
As an industrial bacterium, Bacillus licheniformis DW2 produces bacitracin which is an important antibiotic for many pathogenic microorganisms. Our previous study showed AbrB-knockout could significantly increase the production of bacitracin. Accordingly,
Cheng-Cheng Shu   +6 more
doaj   +1 more source

Refined Pichia pastoris reference genome sequence [PDF]

open access: yesJournal of Biotechnology, 2016
Strains of the species Komagataella phaffii are the most frequently used "Pichia pastoris" strains employed for recombinant protein production as well as studies on peroxisome biogenesis, autophagy and secretory pathway analyses. Genome sequencing of several different P.
Sturmberger   +17 more
openaire   +2 more sources

Will long-read sequencing technologies replace short-read sequencing technologies in the next 10 years?

open access: yesAfrican Journal of Laboratory Medicine, 2020
No abstract available.
Boluwatife A. Adewale
doaj   +1 more source

Reference genome and comparative genome analysis for the WHO reference strain for Mycobacterium bovis BCG Danish, the present tuberculosis vaccine [PDF]

open access: yes, 2019
Background: Mycobacterium bovis bacillus Calmette-Guerin (M. bovis BCG) is the only vaccine available against tuberculosis (TB). In an effort to standardize the vaccine production, three substrains, i.e. BCG Danish 1331, Tokyo 172-1 and Russia BCG-1 were
Borgers, Katlyn   +9 more
core   +2 more sources

The value of new genome references [PDF]

open access: yesExperimental Cell Research, 2017
Genomic information has become a ubiquitous and almost essential aspect of biological research. Over the last 10-15 years, the cost of generating sequence data from DNA or RNA samples has dramatically declined and our ability to interpret those data increased just as remarkably.
Kim C, Worley   +2 more
openaire   +2 more sources

FAIR Header Reference genome: A TRUSTworthy standard

open access: yesBriefings in Bioinformatics, 2023
The lack of interoperable data standards among reference genome data-sharing platforms inhibits cross-platform analysis while increasing the risk of data provenance loss. Here, we describe the FAIR-bioHeaders Reference genome (FHR), a metadata standard guided by the principles of Findability, Accessibility, Interoperability, and Reuse (FAIR) in ...
Adam Wright   +12 more
openaire   +3 more sources

What's in your next-generation sequence data? An exploration of unmapped DNA and RNA sequence reads from the bovine reference individual. [PDF]

open access: yes, 2015
BackgroundNext-generation sequencing projects commonly commence by aligning reads to a reference genome assembly. While improvements in alignment algorithms and computational hardware have greatly enhanced the efficiency and accuracy of alignments, a ...
Alexander, Leeson J   +9 more
core   +1 more source

The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics

open access: yesbioRxiv
A global genome database of all of Earth’s species diversity could be a treasure trove of scientific discoveries. However, regardless of the major advances in genome sequencing technologies, only a tiny fraction of species have genomic information ...
Ann M. Mc Cartney   +200 more
semanticscholar   +1 more source

Limitations of the Human Reference Genome for Personalized Genomics

open access: yesPLoS ONE, 2012
Data from the 1000 genomes project (1KGP) and Complete Genomics (CG) have dramatically increased the numbers of known genetic variants and challenge several assumptions about the reference genome and its uses in both clinical and research settings. Specifically, 34% of published array-based GWAS studies for a variety of diseases utilize probes that ...
Jeffrey A Rosenfeld   +2 more
openaire   +4 more sources

Genomic Characterization of a Wild-Type Bovine alphaherpesvirus 1 (BoAHV-1) Strain Isolated in an Outbreak in Central Italy

open access: yesViruses
Bovine alphaherpesvirus-1 (BoAHV-1) infection is common in cattle worldwide. However, information on the spread of BoAHV-1-circulating strains in Italy remains limited.
Stefano Petrini   +12 more
doaj   +1 more source

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