Results 111 to 120 of about 4,285,228 (287)

Intertextual Episodes in Lectures: A Classification from the Perspective of Incidental Learning from Reading [PDF]

, 2010
In a parallel language environment it is important that teaching takes account of both the languages students are expected to work in.  Lectures in the mother tongue need to offer access to textbooks in English and encouragement to read.
Irvine, Aileen, Malmstrom, Hans, Pecorari, Diane, Shaw, Philip   +3 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Experiences with entomopathogenic nematodes for the control of overwintering codling moth larvae in Germany [PDF]

, 2008
Entomopathogenic nematodes were tested for their potential as tool in resistance management of codling moth Cydia pomonella L. in organic fruit growing. In two field tests, the adults emerging from stems treated with nematodes were monitored.
Kienzle, J., Volk, F., Zebitz, C.P.W., Zimmer, J.   +3 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictive Efficacy of Dual Therapies Combining Integrase Strand Transfer Inhibitors with Second-Generation Non-Nucleoside Reverse Transcriptase Inhibitors Following HIV-1 Treatment Failure in Cameroon: Implications for the Use of a Long-Acting Therapeutic Strategy in Low- and Middle-Income Countries

Viruses
Dual therapies (DT) combining integrase strand transfer inhibitors (INSTIs) with second-generation non-nucleoside reverse transcriptase inhibitors (2nd-Gen-NNRTIs) offer new possibilities for HIV treatment to improve adherence.
Davy-Hyacinthe Gouissi Anguechia, Yagai Bouba, Ezechiel Ngoufack Jagni Semengue, Aude Christelle Ka’e, Désiré Takou, Collins Ambe Chenwi, Grace Beloumou, Alex Durand Nka, Ulrich Roland Basseck Wome, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Adawaye Chatté, Carla Montesano, Giulia Cappelli, Vittorio Colizzi, Alexis Ndjolo, Dora Mbanya, Nicaise Ndembi, Carlo-Federico Perno, Joseph Fokam   +19 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Empowering adolescents living with perinatally-acquired HIV: tailored CD4+ count assessment for optimized care, the EDCTP READY-study

Frontiers in Medicine
BackgroundThe elevated rate of AIDS-related mortality in Sub-Saharan Africa among adolescents living with HIV (ALHIV) is influenced by various factors, notably immunosuppression, within a framework of limited therapeutic alternatives. We aimed to enhance
Willy Le Roi Togna Pabo, Willy Le Roi Togna Pabo, Willy Le Roi Togna Pabo, Aurelie Minelle Kengni Ngueko, Aurelie Minelle Kengni Ngueko, Alex Durand Nka, Alex Durand Nka, Alex Durand Nka, Maria Mercedes Santoro, Yagai Bouba, Yagai Bouba, Collins Ambe Chenwi, Ezéchiel Ngoufack Jagni Semengue, Ezéchiel Ngoufack Jagni Semengue, Ezéchiel Ngoufack Jagni Semengue, Désiré Takou, Georges Teto, Beatrice Dambaya, Raymond Babila Nyasa, Michel Carlos Tommo Tchouaket, Michel Carlos Tommo Tchouaket, Grace Angong Beloumou, Sandrine Claire Djupsa Ndjeyep, Aude Christelle Ka’e, Tatiana Anim Keng Tekoh, Derrick Tambe Ayuk Ngwese, Naomi-Karell Etame, Rachel Audrey Nayang Mundo, Rachel Simo Kamgaing, Samuel Martin Sosso, Roland Ndip Ndip, Vittorio Colizzi, Vittorio Colizzi, Vittorio Colizzi, Francesca Cecchereni-Silberstein, Alexis Ndjolo, Joseph Fokam, Joseph Fokam, Joseph Fokam, Joseph Fokam, Joseph Fokam   +40 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Predicting and Recognizing Drug‐Induced Type I Brugada Pattern Using ECG‐Based Deep Learning

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Brugada syndrome (BrS) has been associated with sudden cardiac death in otherwise healthy subjects, and drug‐induced BrS accounts for 55% to 70% of all patients with BrS.
Paul‐Adrian Călburean, Luigi Pannone, Cinzia Monaco, Domenico Della Rocca, Antonio Sorgente, Alexandre Almorad, Gezim Bala, Filippo Aglietti, Robbert Ramak, Ingrid Overeinder, Erwin Ströker, Gudrun Pappaert, Marius Măru’teri, Marius Harpa, Mark La Meir, Pedro Brugada, Juan Sieira, Andrea Sarkozy, Gian‐Battista Chierchia, Carlo de Asmundis   +19 more
doaj   +1 more source

Mendeley Reference Manager

, 2021
Mendeley Reference ...
openaire   +1 more source