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HIV-1 drug resistance and resistance testing [PDF]
Infection, Genetics and Evolution, 2016 The global scale-up of antiretroviral (ARV) therapy (ART) has led to dramatic reductions in HIV-1 mortality and incidence. However, HIV drug resistance (HIVDR) poses a potential threat to the long-term success of ART and is emerging as a threat to the elimination of AIDS as a public health problem by 2030.
Silvia Bertagnolio +2 more
exaly +3 more sources
Epidemic Characteristics of HIV Drug Resistance in Hefei, Anhui Province
Pathogens, 2022 To study the characteristics of HIV pretreatment drug resistance (PDR) and acquired drug resistance (ADR) in Hefei, a cross-sectional survey was used to collect 816 samples from newly reported HIV infections from 2017 to 2020 and 127 samples from HIV ...
Shan Zheng +14 more
doaj +3 more sources
HIV drug resistance: problems and perspectives
Infectious Disease Reports, 2013 Access to combination antiretroviral treatment (ART) has improved greatly over recent years. At the end of 2011, more than eight million HIV-infected people were receiving ART in low-income and middle-income countries. ART generally works well in keeping the virus suppressed and the patient healthy. However, treatment only works as long as the virus is
Pleuni S. Pennings
exaly +6 more sources
HIV drug resistance and its associated factors among patients during interruption of antiretroviral therapy in China [PDF]
Frontiers in MicrobiologyBackgroundThe prevalence of human immunodeficiency virus (HIV) drug resistance among people living with HIV (PLWH) who experience treatment interruptions is a significant concern.
Zhongbao Zuo +10 more
doaj +2 more sources
HIV Genetic Diversity and Drug Resistance [PDF]
Viruses, 2010 Most of the current knowledge on antiretroviral (ARV) drug development and resistance is based on the study of subtype B of HIV-1, which only accounts for 10% of the worldwide HIV infections. Cumulative evidence has emerged that different HIV types, groups and subtypes harbor distinct biological properties, including the response and susceptibility to ...
Marcelo Alves Soares +1 more
exaly +4 more sources
HIV drug resistance: analysis of viral genotypes and mutation loci in people living with HIV in Chongqing, China (2016–2023) [PDF]
AIDS Research and TherapyBackground Large-scale HIV genotype drug resistance study has not been conducted in Chongqing. Methods A retrospective study was conducted on people living with HIV(PLWH) who received HIV-1 genotype resistance testing at Chongqing Public Health Medical ...
Wenwan Gao +5 more
doaj +2 more sources
A Review: Understanding Molecular Mechanisms of Antibody-Dependent Enhancement in Viral Infections
Vaccines, 2023 Antibody Dependent Enhancement (ADE) of an infection has been of interest in the investigation of many viruses. It is associated with the severity of the infection.
Jyoti Sawant, Ajit Patil, Swarali Kurle
doaj +1 more source
New England Journal of Medicine, 2004 Combinations of antiretroviral drugs have proven remarkably effective in controlling the progression of HIV disease and prolonging survival, but these benefits can be compromised by the development of drug resistance. About 50 percent of patients receiving antiretroviral therapy in the United States are estimated to harbor viruses that express ...
François, Clavel, Allan J, Hance
+5 more sources
BMJ, 2007 HIV has an impressive ability to replicate, mutate, and diversify, so developing drugs or vaccines that can fully contain the virus is a challenge. The only consistently successful way to prevent replication of HIV is to administer a potent combination regimen that contains at least two and preferably three antiretroviral drugs.
Hiroyu, Hatano, Steven G, Deeks
openaire +2 more sources
Frontiers in Microbiology, 2022 Certain rural and semiurban settings in the Unnao district, Uttar Pradesh, India observed an unprecedented increase in the detection of HIV cases during July 2017.
Ajit Patil +5 more
doaj +1 more source