The HIV-1 subtype C epidemic in South America is linked to the United Kingdom. [PDF]
PLoS ONE, 2010 BackgroundThe global spread of HIV-1 has been accompanied by the emergence of genetically distinct viral strains. Over the past two decades subtype C viruses, which predominate in Southern and Eastern Africa, have spread rapidly throughout parts of South
Tulio de Oliveira +3 more
doaj +2 more sources
Current Research on HIV Drug Resistance [PDF]
, 2022 HIV drug resistance is an unavoidable challenge for HIV/AIDS professionals, and it has long been a major obstacle hindering the global effort to contain HIV/AIDS.
core +1 more source
HIV and Drug-Resistant Subtypes
Microorganisms, 2023 Acquired Immunodeficiency Syndrome (AIDS) is a human viral infectious disease caused by the positive-sense single-stranded (ss) RNA Human Immunodeficiency Virus (HIV) (Retroviridae family, Ortervirales order). HIV-1 can be distinguished into various worldwide spread groups and subtypes.
Bianca Maria Nastri +7 more
openaire +3 more sources
Phylodynamic analysis reveals CRF01_AE dissemination between Japan and neighboring Asian countries and the role of intravenous drug use in transmission. [PDF]
PLoS ONE, 2014 BACKGROUND: One major circulating HIV-1 subtype in Southeast Asian countries is CRF01_AE, but little is known about its epidemiology in Japan. We conducted a molecular phylodynamic study of patients newly diagnosed with CRF01_AE from 2003 to 2010 ...
Teiichiro Shiino +5 more
doaj +1 more source
Using machine learning and big data to explore the drug resistance landscape in HIV.
PLoS Computational Biology, 2021 Drug resistance mutations (DRMs) appear in HIV under treatment pressure. DRMs are commonly transmitted to naive patients. The standard approach to reveal new DRMs is to test for significant frequency differences of mutations between treated and naive ...
Luc Blassel +6 more
doaj +1 more source
Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania [PDF]
, 2013 HIV-1 resistance is one of the problems affecting success of antiretroviral therapy programmes worldwide. Many studies on efficacy of ART programmes, specifically on drug resistance, have been conducted in developed countries but not in developing ...
Masimba, Pax Jessey
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Validation of replicative phenotyping to detect and assign HIV-1 resistance in clinical specimens [PDF]
, 2009 The ability of HIV-1 to develop resistance to antiretroviral drugs has limited the overall efficacy of combination therapy to suppress viral replication.
Louvel, Séverine
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Recommendations on data sharing in HIV drug resistance research.
PLoS Medicine, 2023 • Human immunodeficiency virus (HIV) drug resistance has implications for antiretroviral treatment strategies and for containing the HIV pandemic because the development of HIV drug resistance leads to the requirement for antiretroviral drugs that may be
Seth C Inzaule +45 more
doaj +1 more source
Adherence as a predictor of the development of class-specific resistance mutations: the Swiss HIV Cohort Study [PDF]
, 2013 BACKGROUND: Non-adherence is one of the strongest predictors of therapeutic failure in HIV-positive patients. Virologic failure with subsequent emergence of resistance reduces future treatment options and long-term clinical success. METHODS: Prospective
Jürg Böni (36157) +71 more
core +3 more sources
Rapid enzymatic test for phenotypic HIV protease drug resistance [PDF]
, 2003 A phenotypic resistance test based on recombinant expression of the active HIV protease in E. coli from patient blood samples was developed. The protease is purified in a rapid onestep procedure as active enzyme and tested for inhibition by five selected
Machleidt, Werner +5 more
core +1 more source