Results 111 to 120 of about 4,335,239 (285)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Evaluation of the concordance between nasopharyngeal and oropharyngeal swabs in the detection of COVID-19

Journal of Public Health in Africa
Background: Nasopharyngeal swabs (NASO) cause discomfort for patients, which can discourage them from getting tested for COVID-19 and limit case detection. It is therefore necessary to consider an alternative, more comfortable swab.
Michel C. Tommo Tchouaket, Joseph Fokam, Ezéchiel N. Semengue, Yagai Bouba, Collins A. Chenwi, Alex D. Nka, Mirice Mbazo'o, Désiré Takou, Samuel M. Sosso, Grace A. Beloumou, Aude C. Ka’e, Aurelie M. Ngueko, Nadine Fainguem, Laeticia Y. Heunko, Sandrine C. Ndjeyep, Willy L. Pabo, Davy-Hyacinthe G. Anguechia, Naomi-Karell Etame, Evariste Molimbou, Rachel A. Mundo, Aissatou Abba, Gregory-Edie Halle-Ekane, Anne-Cecile Z.K. Bissek, Vittorio Colizzi, Carlo-Federico Perno, Alexis Ndjolo   +25 more
doaj   +1 more source

An Innovative Mission Management System for Fixed-Wing UAVs [PDF]

, 2012
This paper presents two innovative units linked together to build the main frame of a UAV Mis- sion Management System. The first unit is a Path Planner for small UAVs able to generate optimal paths in a tridimensional environment, generat- ing flyable ...
De Filippis, Luca, Guglieri, Giorgio, Quagliotti, Fulvia   +2 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Predictive Efficacy of Dual Therapies Combining Integrase Strand Transfer Inhibitors with Second-Generation Non-Nucleoside Reverse Transcriptase Inhibitors Following HIV-1 Treatment Failure in Cameroon: Implications for the Use of a Long-Acting Therapeutic Strategy in Low- and Middle-Income Countries

Viruses
Dual therapies (DT) combining integrase strand transfer inhibitors (INSTIs) with second-generation non-nucleoside reverse transcriptase inhibitors (2nd-Gen-NNRTIs) offer new possibilities for HIV treatment to improve adherence.
Davy-Hyacinthe Gouissi Anguechia, Yagai Bouba, Ezechiel Ngoufack Jagni Semengue, Aude Christelle Ka’e, Désiré Takou, Collins Ambe Chenwi, Grace Beloumou, Alex Durand Nka, Ulrich Roland Basseck Wome, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Adawaye Chatté, Carla Montesano, Giulia Cappelli, Vittorio Colizzi, Alexis Ndjolo, Dora Mbanya, Nicaise Ndembi, Carlo-Federico Perno, Joseph Fokam   +19 more
doaj   +1 more source

Economic Evaluation of Food Traceability Systems through Reference Models [PDF]

Food supply chains complexity present a real challenge to perform economic evaluation of food traceability systems and their innovation/upgrades. In order to perform a supply chain wide economic evaluation a conceptual framework is developed using food ...
Brofman, Freddy, Garcia Martinez, Marian, Souza Monteiro, Diogo M.   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Empowering adolescents living with perinatally-acquired HIV: tailored CD4+ count assessment for optimized care, the EDCTP READY-study

Frontiers in Medicine
BackgroundThe elevated rate of AIDS-related mortality in Sub-Saharan Africa among adolescents living with HIV (ALHIV) is influenced by various factors, notably immunosuppression, within a framework of limited therapeutic alternatives. We aimed to enhance
Willy Le Roi Togna Pabo, Willy Le Roi Togna Pabo, Willy Le Roi Togna Pabo, Aurelie Minelle Kengni Ngueko, Aurelie Minelle Kengni Ngueko, Alex Durand Nka, Alex Durand Nka, Alex Durand Nka, Maria Mercedes Santoro, Yagai Bouba, Yagai Bouba, Collins Ambe Chenwi, Ezéchiel Ngoufack Jagni Semengue, Ezéchiel Ngoufack Jagni Semengue, Ezéchiel Ngoufack Jagni Semengue, Désiré Takou, Georges Teto, Beatrice Dambaya, Raymond Babila Nyasa, Michel Carlos Tommo Tchouaket, Michel Carlos Tommo Tchouaket, Grace Angong Beloumou, Sandrine Claire Djupsa Ndjeyep, Aude Christelle Ka’e, Tatiana Anim Keng Tekoh, Derrick Tambe Ayuk Ngwese, Naomi-Karell Etame, Rachel Audrey Nayang Mundo, Rachel Simo Kamgaing, Samuel Martin Sosso, Roland Ndip Ndip, Vittorio Colizzi, Vittorio Colizzi, Vittorio Colizzi, Francesca Cecchereni-Silberstein, Alexis Ndjolo, Joseph Fokam, Joseph Fokam, Joseph Fokam, Joseph Fokam, Joseph Fokam   +40 more
doaj   +1 more source