Results 131 to 140 of about 10,227,134 (294)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Variance, norms and cooperative behavior in public goods games

open access: yesFrontiers in Psychology
This study examines the relationship between the variance of others’ contributions, social norms (empirical and normative expectations), and cooperative behavior using a classic linear public goods game. The following results are observed.
Guangrong Wang   +7 more
doaj   +1 more source

Tibial reference point in total knee arthroplasty in patient with proximal tibia vara: A case report. [PDF]

open access: yesInt J Surg Case Rep, 2022
Butarbutar JCP   +3 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Outstanding Business Reference Sources: The 2011 Selection of Recent Titles

open access: yes, 2012
A selection of business reference sources for ...
BRASS Business Reference Sources Committee
core  

Reference-point dependent reinforcement learning in humans and rats. [PDF]

open access: yesNat Commun
Ferguson LA   +4 more
europepmc   +2 more sources

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