Results 131 to 140 of about 4,099,878 (253)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Insurance Policies for Monetary Policy in the Euro Area [PDF]
In this paper, we examine the cost of insurance against model uncertainty for the Euro area considering four alternative reference models, all of which are used for policy-analysis at the ECB.We find that maximal insurance across this model range in ...
Keith Küster, Volker Wieland
core
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Noninformative priors in Bayesian analysis
, 1990 The reference priors, introduced by Bernardo (1979) and as further developed in Berger and Bernardo (1989a,b,c), are studied in several situations. These include nonlinear regression, sequential problems, and the unbalanced variance components problem ...
Ye, Keying
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Probability matching priors for linear calibration
Bayesian Inference, Inverse Regression, Jeffreys Prior, Markov Chain Monte Carlo Methods, Reference Priors,
B. Carlin, M. Ghosh, M. Srivastava
core +1 more source
Improved Bayesian Inferences for Right-Censored Birnbaum–Saunders Data
MathematicsThis work focuses on making Bayesian inferences for the two-parameter Birnbaum–Saunders (BS) distribution in the presence of right-censored data. A flexible Gibbs sampler is employed to handle the censored BS data in this Bayesian work that relies on ...
Kalanka P. Jayalath
doaj +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Hellinger distance and non-informative priors
, 2011 This paper introduces an extension of the Jeffreys’ rule to the construction of objective priors for non-regular parametric families. A new class of priors based on Hellinger information is introduced as Hellinger priors.
Shemyakin, Arkady
core
Reference-Guided Image Enhancement with Retinex Priors and Diffusion Models [PDF]
Image restoration, particularly low-light and compression artifact removal, remains a challenging problem due to severe loss of illumination, color distortion, and high-frequency detail degradation. Traditional methods often struggle to preserve semantic
Seth, Siddharth
core +1 more source