Results 131 to 140 of about 28,569 (299)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Scientific ReportsReal-time fire detection and precise geographic localization using unmanned aerial vehicles (UAVs) are critical for early forest-fire warning. However, existing approaches face a fundamental dilemma: achieving high detection accuracy requires complex ...
Haiwen Yin +5 more
doaj +1 more source
Physical Sciences ForumWhen the quantities of interest remain underdetermined a posteriori, we would like to draw inferences for at least one particular solution. Can we do so in a Bayesian way? What is a probability distribution over an underdetermined quantity? How do we get
Fabrice Pautot
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Some Remarks on Consistency and Strong Inconsistency of Bayesian Inference
The paper provides new sufficient conditions for consistent and coherent Bayesian inference when a model is invariant under some group of transformations.
Kociecki, Andrzej
core
Hellinger distance and non-informative priors
, 2011 This paper introduces an extension of the Jeffreys’ rule to the construction of objective priors for non-regular parametric families. A new class of priors based on Hellinger information is introduced as Hellinger priors.
Shemyakin, Arkady
core
Prior elicitation and variable selection for bayesian quantile regression [PDF]
, 2013 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Bayesian subset selection suffers from three important difficulties: assigning priors over model space, assigning priors to all components of the regression
Al-Hamzawi, Rahim Jabbar Thaher
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Noninformative priors for the normal variance ratio
Frequentist coverage probability, Probability matching priors, Ratio of variances, Reference priors,
D. Kim, S. Kang, W. Lee
core +1 more source