Results 111 to 120 of about 112,532 (287)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
O Livro Azul sobre o solipsismo e os usos do ‘Eu’: Uma leitura dialética
DoisPontos, 2012 This paper argues for a dialectical reading of Wittgenstein’s grammatical reminders concerning the uses of the first person pronoun in The Blue Book. Against a widespread, ‘non-referential’ view which takes those reminders as direct attempts
Jônadas Techio
doaj
Can there be a Chinese Philosophy? -- a Review of Searle's Philosophy and Chinese Philosophy--Bo Mou Ed 440p (2008)(review revised 2019) [PDF]
, 2019 This book is invaluable as a synopsis of some of the work of one the greatest philosophers of recent times. There is much value in analyzing his responses to the basic confusions of philosophy, and in the generally excellent attempts to connect classical
Starks, Michael
core +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
A NUMERICAL STUDY OF WATER PROPAGATION AND BREAKING USING SPH METHOD [PDF]
Journal of Engineering Science and Technology, 2017 A breaking wave is a violent natural event that involves highly complex phenomena, such as large deformation of free surface, turbulence, vortex generation, strong interaction between wave and structures, etc.
COELHO J. G. +3 more
doaj
Metaphorical Singular Reference. The Role of Enriched Composition in Reference Resolution
The Baltic International Yearbook of Cognition, Logic and Communication, 2008 It is widely accepted that, in the course of interpreting a metaphorical utterance, both literal and metaphorical interpretations of the utterance are available to the interpreter, although there may be disagreement about the order in which these ...
Anne Bezuidenhout
doaj +1 more source
Definitions in ontologies [PDF]
, 2016 Definitions vary according to context of use and target audience. They must be made relevant for each context to fulfill their cognitive and linguistic goals.
Ruttenberg, Alan +3 more
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
How Generative AI Is Reshaping Student Writing: A Data-Driven Perspective for Writing Instructors
Education SciencesGenerative AI has rapidly entered college writing classrooms, raising practical questions about how student texts are changing and what that means for instruction.
Maryam Eslami +2 more
doaj +1 more source