Results 161 to 170 of about 112,532 (287)

Resolving Temporary Referential Ambiguity Using Presupposed Content [PDF]

open access: yes, 2014
Jacopo Romoli   +3 more
openaire   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Three dimensions of speech coherence in people with early psychosis and their family members. [PDF]

open access: yesSchizophrenia (Heidelb)
Çokal D   +7 more
europepmc   +1 more source

Specific patterns of referential use in Mandarin-Italian bilingual children

open access: yesZAS Papers in Linguistics
In a recent study on Mandarin-English bilingual children, Zhou et al. (2022) identified two specific patterns in Mandarin productions: the overuse of demonstrative NPs in referent reintroductions among bilinguals compared to monolinguals and the preference for preverbal order when introducing new referents.
openaire   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Upalaksana and “Referential Use”

open access: yesJOURNAL OF INDIAN AND BUDDHIST STUDIES (INDOGAKU BUKKYOGAKU KENKYU), 1997
openaire   +2 more sources

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