Results 71 to 80 of about 8,013 (292)

“Definite Associative Deixis”: Between Referential and Attributive Readings

open access: yesDiscours
This paper investigates different readings of definite descriptions within “definite associative deixis”. The term itself was proposed in Dvořák (2023) to refer to Hawkins’ “larger situation uses based on general knowledge” (1978).
Jan Dvořák
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Fatigue, Indolence And The There Is, Or, The Temporal Logic Of Collage In Donald Barthelme’s Snow White

open access: yesEuropean Journal of American Studies, 2010
The essay examines Donald Barthelme’s Snow White’s from the perspective of the ethical philosophy of Emmanuel Levinas. Drawing on a reciprocity between Barthelme’s collage principle and Levinas’s notion of the there is, the paper applies the concept in ...
Zuzanna Ładyga
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

A Referential Analysis of Fictional Names

open access: yes, 2016
Do fictional names refer to fictional characters? Realists argue they do, while anti-realists argue they do not. According to referentialism, a proper name contributes its referent to the singular proposition expressed by sentences of which the name is a
Hurry, Dylan
core   +1 more source

Derivation of SPH equations in a moving referential coordinate system [PDF]

open access: yes, 2009
The conventional SPH method uses kernel interpolation to derive the spatial semi-discretisation of the governing equations. These equations, derived using a straight application of the kernel interpolation method, are not used in practice. Instead the
Jaric, J.   +3 more
core   +1 more source

The Speech Act of Naming in Fictional Discourse

open access: yesStudia Semiotyczne, 2022
DOI: https://doi.org/10.26333/sts.xxxvi1.08 This paper argues that García-Carpintero’s theory of proper names (the Mill-Frege theory) and his theory of fiction-making do not work well together.
Amalia Haro Marchal
doaj  

Où est "ailleurs" ? Sémantique lexicale de l'adverbe spatial "ailleurs".

open access: yesCorela, 2013
Like other words, we think that the French spatial adverbial ailleurs contains two kinds of information: a conceptual meaning and a procedural meaning that depends on the semantico-referential process it involves. This article postulates that ailleurs is
Marie Lammert
doaj   +1 more source

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