Results 71 to 80 of about 2,511,094 (288)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Production and comprehension of gestures between orang-utans (Pongo pygmaeus) in a referential communication game [PDF]

, 2015
Orang-utans played a communication game in two studies testing their ability to produce and comprehend requestive pointing. While the 'communicator' could see but not obtain hidden food, the 'donor' could release the food to the communicator, but could ...
Josep Call, Josep Call (109947), Moore, R. ; https://orcid.org/, Michael Tomasello (31692), Call, Josep, Tomasello Michael, Richard Moore (2297), Tomasello, M. ; https://orcid.org/, Tomasello, Michael, Moore Richard, Moore, Richard, Michael Tomasello, Call, J. ; https://orcid.org/, Richard Moore, Call Josep   +14 more
core   +2 more sources

SEMANTIC CHANGE AND MEANING SHIFT ANALYSIS ON FILM MAKING TERMS [PDF]

, 2010
Meaning change refers to the changes of word meaning that replace the original meaning. In film making terms, many meaning change has occured that makes the meaning of word may become broader, narrower, positive or negative.
TOBING, SEPTIKA S
core   +1 more source

The Sociopragmatic Mechanism for the Referential Usages of “Renjia”

Вестник Новосибирского государственного университета. Серия: история, филология
The use of language is a comprehensive assessment, selection and decision-making process. A single and one-sided perspective cannot satisfactorily explain the sociopragmatic factors on which speakers rely when using the referential word “Renjia”. “Renjia”
Hongjun Fu, Miaolu Wu
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

“Are we up to the task?”: exploring the syntactic and semantic frontiers of X be up to Y and other aspectual-modal idioms

Anglophonia
This paper aims to characterize X be up to Y, an idiom associated with four different syntactic and referential constructions, each associated with distinct yet related aspectual and modal meanings.
Manon Philippe
doaj   +1 more source

Noise Reduction in Time Domain Using Referential Reconstruction

IEICE Transactions on Information and Systems, 2006
We present a novel approach for single-channel noise reduction of speech signals contaminated by additive noise. In this approach, the system requires speech samples to be uttered in advance by the same speaker as that of the input signal. Speech samples used in this method must have enough phonetic variety to reconstruct the input signal.
Takehiro Ihara, Takayuki Nagai, Kazuhiko Ozeki, Akira Kurematsu   +3 more
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Acts of reference and the miscommunication of referents by first and second language speakers of English [PDF]

, 2012
Central to communication are acts of reference, in which speakers clarify to hearers the identity of specific individuals (referents) through the use of referring expressions.
Ryan, Jonathon
core