Results 91 to 100 of about 157,821 (303)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Flexure of thick orthotropic plates by exponential shear deformation theory

Latin American Journal of Solids and Structures
In the present paper, a variationally consistent exponential shear deformation theory taking into account transverse shear deformation effect is presented for the flexural analysis of thick orthotropic plates.
A. S. Sayyad
doaj   +1 more source

A refined shear deformation theory for the analysis of laminated plates [PDF]

A refined, third-order plate theory that accounts for the transverse shear strains is presented, the Navier solutions are derived for certain simply supported cross-ply and antisymmetric angle-ply laminates, and finite-element models are developed for ...
Reddy, J. N.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Modified Bolle - Reissner Theory of Plates Including Transverse Shear Deformations

Latin American Journal of Solids and Structures
In this work, new equations for first-order shear deformation plates are deduced taking into account the kinematic assumptions of the Bolle-Reissner theory but considering the equilibrium equations in the deformed configuration for the plate.
J. M. Martínez Valle, P. Martínez-Jiménez   +1 more
doaj   +1 more source

Visibility-based hypothesis testing using higher-order optical interference

, 2018
Many quantum information protocols rely on optical interference to compare datasets with efficiency or security unattainable by classical means. Standard implementations exploit first-order coherence between signals whose preparation requires a shared ...
Banaszek, Konrad, Jachura, Michał, Jarzyna, Marcin, Lipka, Michał, Wasilewski, Wojciech   +4 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Mechanical Stability Investigation of Advanced Composite Plates Resting on Elastic Foundations Using a New Four-Unknown Refined Theory

Fracture and Structural Integrity, 2019
A refined and simple shear deformation theory for mechanical buckling of composite plate resting on two-parameter Pasternak’s foundations is developed. The displacement field is chosen based on assumptions that the in-plane and transverse displacements ...
Yassine khalfi, Aboubakar Seddik BOUCHIKHI, Yassine BELLEBNA   +2 more
doaj   +3 more sources

Triangular Layered Finite Element Method for Reinforced Concrete Slabs

Structural Mechanics of Engineering Constructions and Buildings
This study presents an advanced layered triangular finite element method for modeling reinforced concrete (RC) slabs, incorporating material nonlinearity based on a refined global-local plate theory.
Dara A. Mawlood, Alexandr A. Koyankin
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source