Results 51 to 60 of about 157,821 (303)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Dynamic instability of imperfect laminated sandwich plates with in-plane partial edge load

Latin American Journal of Solids and Structures
Dynamic instability of laminated sandwich plates having inter-laminar imperfections with in-plane partial edge loading is studied for the first time using an efficient finite element plate model.
Anupam Chakrabarti, Abdul Hamid Sheikh
doaj   +1 more source

Approximation Techniques for Planar Periodic Structures [PDF]

, 1985
The rigorous calculation of electromagnetic properties of periodic meshes using moment methods requires considerable algebraic work and computer resources. In this paper, a number of easy to use approximation techniques for analyzing thin structures with
Compton, Richard C., Rutledge, David B.
core   +1 more source

Refined theory for linearly elastic plates: Laminae and laminates [PDF]

Mathematics and Mechanics of Solids, 2011
It is well known that bending and stretching modes of deformation in linearly-elastic plates decouple at leading order in thickness provided that the mid-plane is a plane of reflection symmetry of the three-dimensional material properties. This situation being the exception rather than the norm, it is important to have a model that accommodates ...
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Исследование динамического деформирования пластины на основе одного волнового уравнения [PDF]

, 2011
Исследуется нестационарное деформирование прямоугольной упругой изотропной пластины под действием импульсных нагрузок. Динамическое поведение пластины описывается в рамках уточненной теории первого порядка на основе одного волнового уравнения ...
Воропай, Н. И., Янютин, Евгений Григорьевич   +1 more
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Evaluation of the Best New Cross-ply Laminated Plate Theories through the Axiomatic/Asymptotic Approach [PDF]

Journal of Applied and Computational Mechanics, 2018
This paper presents Best Theory Diagrams (BTDs) constructed from various non-polynomial theories for the static analysis of thick and thin symmetric and asymmetric cross-ply laminated plates. The BTD is a curve that provides the minimum number of unknown
S. Candiotti, J.L. MANTARI
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Analysis of the mechanical behavior of functional gradient porous plates on an elastic foundation

Scientific African
Summary: This study presents an in-depth analysis of the bending behavior of porous functionally graded material (P-FGM) plates resting on a Winkler–Pasternak elastic foundation. Two types of transverse loading are considered: uniform and sinusoidal. The
Karim Fikri, Khalid Adnaoui, Laila Mouakkir   +2 more
doaj   +1 more source