Results 71 to 80 of about 157,821 (303)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Thermal Buckling Analysis of Laminated Composite Plates Using Four-Variable Refined Plate Theory

Journal of Engineering
This paper investigates the thermal buckling of laminated composite plates based on a refined plate theory that incorporates four variables, using hyperbolic and polynomial shear strain functions for the first time to analyze thermal buckling of a ...
Ahmed Khamees Sabea , Widad Ibraheem Majeed   +1 more
doaj   +1 more source

Heat transfer during film condensation of potassium vapor on a horizontal plate [PDF]

, 1968
The object of the investigation is to analyze the following two features of heat transfer during condensation of potassium vapor: a. Heat transfer during film condensation of a pure saturated potassium vapor on a horizontal surface. b.
Meyrial, Paul M., Morin, Michel L.
core  

A virtual element method for the vibration problem of Kirchhoff plates [PDF]

, 2017
The aim of this paper is to develop a virtual element method (VEM) for the vibration problem of thin plates on polygonal meshes. We consider a variational formulation relying only on the transverse displacement of the plate and propose an $H^2(\Omega ...
Mora, David, Rivera, Gonzalo, Velásquez, Iván   +2 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Crystal structure of the high-pressure phase of the oxonitridosilicate chloride Ce4[Si4O3 + xN7 − x]Cl1 − xOx, x≃0.2 [PDF]

, 2006
The structural compression mechanism of Ce4[Si4O3 + xN7 − x]Cl1 − xOx, x≃ 0.2, was investigated by in situ single-crystal synchrotron X-ray diffraction at pressures of 3.0, 8.5 and 8.6 GPa using the diamond–anvil cell technique.
Friedrich, Alexandra, Haussühl, Eiken, Knorr, Karsten, Lieb, Alexandra, Morgenroth, Wolfgang, Schnick, Wolfgang, Winkler, Björn   +6 more
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Free vibration of a micro-scale composite laminated Reddy plate using a finite element method based on the new modified couple stress theory

Results in Physics, 2020
In this study, a non-confirming element which is a combination of the BCIZ and refined triangular non-conforming element is developed for the free vibration analysis of micro-scale angle-ply laminated Reddy plate based on the new modified couple stress ...
Yunlong Ma, Yihang Gao, Wanli Yang, Dan He   +3 more
doaj   +1 more source