Results 141 to 150 of about 112,147 (264)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Refinement and Preliminary Validation of the Technological Competency as Caring in Healthcare Instrument (TCCHI): Psychometric Evaluation of a Concise Three-Factor Model. [PDF]

Healthcare (Basel)
Yamanaka R, Ito H, Takashima Y, Soriano K, Onishi K, Betriana F, Soriano GP, Blaquera AP, Akiyama T, Tanioka R, Kwan RYC, Viernes JB, Miyagawa M, Osaka K, Yasuhara Y, Akaike M, Tanioka T.   +16 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Inside the black box: Refining programme theory in the PriDem dementia care study. [PDF]

PLoS One
Griffiths S, Spencer E, Robinson L, Rait G, PriDem Study Team.   +4 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Developing community-based programme theories to address unmet needs of people experiencing homelessness and severe mental illness: protocol for a realist review. [PDF]

NIHR Open Res
Abayneh S, Asher L, Smartt C, Mutiso V, Yaro PB, Misganaw E, Kariuki K, Mukami F, Fofo CA, Legend TH, Chenu H, Read U, Mayston R, Birhanu R, Alem A, Hanlon C.   +15 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

5-Amino-levulinic acid hydro-chloride. [PDF]

IUCrdata
Ducreux JG, Kaduk JA, Dosen A, Blanton TN.   +3 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Conceptualization, Contexts, and Measurement of Nursing Theoretical Literacy: Protocol for a Scoping Review. [PDF]

JMIR Res Protoc
Ge J, Song H, Yang J, Feng Y, Zheng T, Wang M, You M, Peng S.   +7 more
europepmc   +1 more source