Results 131 to 140 of about 5,714,792 (303)

The refined theory for a magnetoelastic body - II. Plane problems

open access: yes, 2010
Without employing ad hoc stress or deformation assumptions, various two-dimensional equations and solutions for plane problems have been deduced systematically and directly from thick plate theory by using the general solution of magnetoelastic theory ...
Gao, Yang, Xu, Bai-Xiang
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

The refined theory and the decomposed theorem of a transversely isotropic elastic plate

open access: yes, 2013
The refined theory of a transversely isotropic elastic plate is analysed. Based on the transversely isotropic elastic theory, a refined theory for bending thick plates is derived using the Elliott-Lodge's solution and Lur'e method without ad ...
Wang, Min-zhong, Zhao, Bao-sheng, Wu, Di
core   +1 more source

A refined theory of magnetoelastic buckling matches experiments with ferromagnetic and superparamagnetic rods. [PDF]

open access: yesProc Natl Acad Sci U S A, 2015
Gerbal F   +5 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Proof Assistance for Refinement in Type Theory

open access: yesElectronic Notes in Theoretical Computer Science, 2000
AbstractIn this paper, we represent in type theory a proof system for refinement of algebraic specifications in ASL [10]. The representation is not adequate but full because the use of proof obligations to represent side-conditions. Using this representation, we can develop a proof tactic to help the development of proofs of refinement.
openaire   +1 more source

Vibration analysis of laminated plates using a refined shear deformation-theory

open access: yes, 1994
A previously published discrete-layer shear deformation theory is used to analyze free vibration of laminated plates. The theory includes the assumption that the transverse shear strains across any two layers are linearly dependent on each other.
Ma BA   +2 more
core   +1 more source

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