Results 111 to 120 of about 5,714,792 (303)

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Motivic homotopy theory and refined enumerative geometry

open access: yes, 2020
This volume contains the proceedings of the Workshop on Motivic Homotopy Theory and Refined Enumerative Geometry, held from May 14-18, 2018, at the Universität Duisburg-Essen, Essen, Germany.
Nguyen, Manh Toan   +2 more
core  

Refined General Theory of Stress Analysis for Tubesheet

open access: yes, 2017
The stress analysis method for fixed tubesheet (TS) heat exchangers (HEX) in pressure vessel codes such as ASME VIII-1, EN13445, and GB151 is based on the classical theory of thin plate on elastic foundation.
Hongsong Zhu
core   +1 more source

A refined difference field theory for symbolic summation [PDF]

open access: yes, 2007
In this article we present a refined summation theory based on Karr’s difference field approach. The resulting algorithms find sum representations with optimal nested depth.
Schneider, Carsten, Carsten Schneider
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Further study on the refined theory of rectangle deep beams

open access: yes, 2013
Based on the refined theory for narrow rectangular deep beams, two different displacement boundary conditions of the fixed end of a cantilever beam are used to study the deformation of the beam.
Shang, Lan-Ge   +3 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Refined plate theory and its variants

open access: yes, 2002
The development of a new refined plate theory and its two simple variants is given. The theories have strong commonality with the equations of classical plate theory (CPT).
SHIMPI, RP
core   +1 more source

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