Results 101 to 110 of about 1,353,441 (297)

Hands on Methods for High Resolution Cryo-Electron Microscopy Structures of Heterogeneous Macromolecular Complexes

Frontiers in Molecular Biosciences, 2019
Electron microscopy of frozen hydrated samples (cryo-EM) is a powerful structural technique that allows the direct study of functional macromolecular complexes in an almost physiological environment.
Marina Serna
doaj   +1 more source

Successive Wyner-Ziv Coding Scheme and its Application to the Quadratic Gaussian CEO Problem

, 2006
We introduce a distributed source coding scheme called successive Wyner-Ziv coding. We show that any point in the rate region of the quadratic Gaussian CEO problem can be achieved via the successive Wyner-Ziv coding.
Berger, Toby, Chen, Jun
core   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Two-dimensional AMR simulations of colliding flows

, 2009
Colliding flows are a commonly used scenario for the formation of molecular clouds in numerical simulations. Due to the thermal instability of the warm neutral medium, turbulence is produced by cooling.
Agertz, Audit, Bakes, Berger, Berger, Commerçon, Federrath, Ferrière, Fryxell, Habing, Heitsch, Hennebelle, Hennebelle, Hennebelle, J. C. Niemeyer, M. Niklaus, Monaghan, O'Shea, Padoan, Schmidt, Stone, Stone, Stone, Teyssier, Vázquez-Semadeni, W. Schmidt, Walder, Wolfire, Wolfire   +28 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Refinement influence in the cleaning efficacy of rotary nickel-titanium Mtwo ® instruments in oval-shaped canals by means of optical microscopy

Indian Journal of Dental Research, 2014
Objective: This study evaluated the cleaning efficacy of the rotary nickel-titanium Mtwo ® by means of optical microscopy in oval-shaped root canals and compared refinement influence using ultrasonic files or Hedströem files.
Cibella Maymone Pontes, Luciana Moura Sassone, Cristiana Francescutti Murad, Rivail Antônio Sérgio Fidel, Fernando Sili Vilhena   +4 more
doaj   +1 more source

The Beilinson regulator is a map of ring spectra

, 2018
We prove that the Beilinson regulator, which is a map from $K$-theory to absolute Hodge cohomology of a smooth variety, admits a refinement to a map of $E_\infty$-ring spectra in the sense of algebraic topology.
Barwick, Beilinson, Blumberg, Bunke, Bunke, Bunke, Burgos, Day, Deligne, Deligne, Drew, Déglise, Feliu, Gepner, Gepner, Gillet, Glasman, Holmstrom, Jardine, Joyal, Lurie, Lurie, Mazel-Gee, Morel, Naumann, Nikolaus, Peters, Robalo, Spitzweck, Weibel   +29 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Pain Management for Animals Used in Science: Views of Scientists and Veterinarians in Canada

Animals, 2014
To explore the challenges and opportunities for pain management for animals used in research an interview study with 9 veterinarians, 3 veterinarian-scientists and 9 scientists, all engaged in animal-based studies in Canada, was carried out. Our broader
Nicole Fenwick, Shannon E. G. Duffus, Gilly Griffin   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source