Results 101 to 110 of about 553,328 (316)

Structure Refinement for Vulnerability Estimation Models using Genetic Algorithm Based Model Generators [PDF]

open access: yes
In this paper, a method for model structure refinement is proposed and applied in estimation of cumulative number of vulnerabilities according to time. Security as a quality characteristic is presented and defined.
Adrian VISOIU
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Meeting Report of the 34th Annual Meeting of the Academy of Surgical Research: Summary of Presentations, Labs, and Workshops, Focusing on Experimental Surgery, Charleston, SC, September 26–28, 2018

open access: yesJournal of Investigative Surgery, 2019
The 34th Annual Meeting of the Academy of Surgical Research was held from September 26–28, 2018 in Charleston, South Carolina. The Academy’s community joins together at the annual meeting to promote and advance professional and academic standards ...
Melanie L. Graham   +2 more
doaj   +1 more source

Hands on Methods for High Resolution Cryo-Electron Microscopy Structures of Heterogeneous Macromolecular Complexes

open access: yesFrontiers in Molecular Biosciences, 2019
Electron microscopy of frozen hydrated samples (cryo-EM) is a powerful structural technique that allows the direct study of functional macromolecular complexes in an almost physiological environment.
Marina Serna
doaj   +1 more source

A Refinement Calculus for Circus - Mini-thesis [PDF]

open access: yes, 2004
Most software developments do not use any of the existing theories and formalisms. This leads to a loss of precision and correctness on the resulting softwares. Two different approaches to formal techniques have been raised in the past decades: one focus
Oliveira, Marcel V. M.
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Refinement influence in the cleaning efficacy of rotary nickel-titanium Mtwo ® instruments in oval-shaped canals by means of optical microscopy

open access: yesIndian Journal of Dental Research, 2014
Objective: This study evaluated the cleaning efficacy of the rotary nickel-titanium Mtwo ® by means of optical microscopy in oval-shaped root canals and compared refinement influence using ultrasonic files or Hedströem files.
Cibella Maymone Pontes   +4 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Pain Management for Animals Used in Science: Views of Scientists and Veterinarians in Canada

open access: yesAnimals, 2014
To explore the challenges and opportunities for pain management for animals used in research an interview study with 9 veterinarians, 3 veterinarian-scientists and 9 scientists, all engaged in animal-based studies in Canada, was carried out. Our broader
Nicole Fenwick   +2 more
doaj   +1 more source

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