Results 111 to 120 of about 553,328 (316)
The Effect of Grain Refinement on the Castability of Magnesium-Aluminium Alloys
, 2007 Rapidly increasing fuel prices and global pressures to reduce the harmful effects of vehicle emissions are forcing vehicle manufacturers to look at alternative materials to reduce the mass of the vehicles they produce.
Timothy Kevin Loughnane +1 more
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Refinement for Probabilistic Systems with Nondeterminism
, 2011 Before we combine actions and probabilities two very obvious questions should be asked. Firstly, what does "the probability of an action" mean? Secondly, how does probability interact with nondeterminism?
Reeves, Steve +3 more
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
zxy1012-maker/Elevated-duct-height-Refinement: 2024.1.3 EleDH Refinement Software and Dataset
<p><strong>Full Changelog</strong>: https://github.com/zxy1012-maker/Elevated-duct-height-Refinement/commits/v1.0.0 This is the first release. The dataset and software in the link are applied in an accepted paper - A Method for Elevated
Zhu, Xunyang
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Diagonal Matrix Reduction over Refinement Rings
پژوهشهای ریاضی, 2022 : A ring R is called a refinement ring if the monoid of finitely generated projective R- modules is refinement. Let R be a commutative refinement ring and M, N, be two finitely generated projective R-nodules, then M~N if and only if Mm ~Nm for all ...
Marjan Sheibani Abdolyousefi +2 more
doaj