Results 131 to 140 of about 553,328 (316)
AnimalsThe validation of methods for understanding the effects of many diseases and treatments requires the use of animal models in translational research. In this context, sheep have been employed extensively in scientific studies.
Beatriz Leandro Bonafini +7 more
doaj +1 more source
A method for maintaining new software [PDF]
, 1994 This thesis describes a novel method for perfective maintenance of software which has been developed from specifications using formal transformations. The list of applied transformations provides a suitable derivation history to use when changes are made
Newton, Jennifer Louise
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Guarded operations, refinement and simulation
, 2009 Simulation rules have long been used as an effective computational means to decide refinement relations in state-based formalisms. Here we investigate how they might be amended so as to decide the event-based notion of singleton failures refinement of ...
Reeves, Steve, Streader, David
core +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Architectural Refinement in HETS [PDF]
, 2012 The main objective of this work is to bring a number of improvements to the Heterogeneous Tool Set HETS, both from a theoretical and an implementation point of view.
Codescu, Mihai
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FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
, 2013 Includes bibliographical references.Wrought Ti6Al4V has attractive mechanical properties but its usage is limited to highend aerospace applications because it is costly to machine components from wrought stock.
Vilane, Velile Nicholine
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