Results 111 to 120 of about 756,391 (343)

Hands on Methods for High Resolution Cryo-Electron Microscopy Structures of Heterogeneous Macromolecular Complexes

Frontiers in Molecular Biosciences, 2019
Electron microscopy of frozen hydrated samples (cryo-EM) is a powerful structural technique that allows the direct study of functional macromolecular complexes in an almost physiological environment.
Marina Serna
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

AMReX: a framework for block-structured adaptive mesh refinement

Journal of Open Source Software, 2019
Author(s): Zhang, Weiqun; Almgren, Ann; Beckner, Vince; Bell, John; Blaschke, Johannes; Chan, Cy; Day, Marcus; Friesen, Brian; Gott, Kevin; Graves, Daniel; Katz, Max; Myers, Andrew; Nguyen, Tan; Nonaka, Andrew; Rosso, Michele; Williams, Samuel; Zingale ...
Weiqun Zhang, A. Almgren, V. Beckner, J. Bell, Johannes Blaschke, Cy Chan, M. Day, B. Friesen, K. Gott, D. Graves, M. Katz, A. Myers, T. Nguyen, A. Nonaka, M. Rosso, S. Williams, M. Zingale   +16 more
semanticscholar   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Refinement influence in the cleaning efficacy of rotary nickel-titanium Mtwo ® instruments in oval-shaped canals by means of optical microscopy

Indian Journal of Dental Research, 2014
Objective: This study evaluated the cleaning efficacy of the rotary nickel-titanium Mtwo ® by means of optical microscopy in oval-shaped root canals and compared refinement influence using ultrasonic files or Hedströem files.
Cibella Maymone Pontes, Luciana Moura Sassone, Cristiana Francescutti Murad, Rivail Antônio Sérgio Fidel, Fernando Sili Vilhena   +4 more
doaj   +1 more source

Editorial: Noninvasive tests for metabolic dysfunction‐associated steatotic liver disease: A refinement of the Nash‐FibroTest for type 2 diabetes mellitus [PDF]

, 2023
Chen‐Hua Liu
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Pain Management for Animals Used in Science: Views of Scientists and Veterinarians in Canada

Animals, 2014
To explore the challenges and opportunities for pain management for animals used in research an interview study with 9 veterinarians, 3 veterinarian-scientists and 9 scientists, all engaged in animal-based studies in Canada, was carried out. Our broader
Nicole Fenwick, Shannon E. G. Duffus, Gilly Griffin   +2 more
doaj   +1 more source

Erratum: Daniels MP, et al. Rodent nerve-muscle cell culture system for studies of neuromuscular junction development: Refinements and applications. Micros Res Tech 49:26-37. [PDF]

, 2000

openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source