Results 61 to 70 of about 553,328 (316)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Evaluating Behavioral Management Practices for Laboratory Nonhuman Primates: An International Survey

Animals
The largest survey to date of behavioral management practices among facilities breeding and housing nonhuman primates (NHPs) for research was conducted from 2019 to 2020.
Kate C. Baker, Fiona R. Sewell, Mark J. Prescott   +2 more
doaj   +1 more source

Local Cisplatin Delivery in Mouse Reliably Models Sensorineural Ototoxicity Without Systemic Adverse Effects

Frontiers in Cellular Neuroscience, 2021
Cisplatin is a lifesaving chemotherapeutic drug with marked ototoxic adverse effects. Cisplatin-induced hearing loss affects a significant part of cancer-surviving patients and is an unmet clinical need with important socioeconomic consequences ...
German Nacher-Soler, Sébastien Lenglet, Marta Coelho, Aurélien Thomas, Aurélien Thomas, François Voruz, François Voruz, Karl-Heinz Krause, Pascal Senn, Pascal Senn, Francis Rousset   +10 more
doaj   +1 more source

Harmonising the definition of refinement [PDF]

, 2005
Russell and Burch's Three Rs (replacement, reduction and refinement) remain the cornerstone for principles guiding humane experimental research. However, the concept of refinement has evolved considerably since its first inception and there have been ...
Morton, David B, Vitale, Augusto, Pollo, Simone, Rennie, Anita, Buchanan-Smith, Hannah M, Prescott, Mark J   +5 more
core  

Incompleteness of relational simulations in the blocking paradigm [PDF]

, 2010
Refinement is the notion of development between formal specifications For specifications given in a relational formalism downward and upward simulations are the standard method to verify that a refinement holds their usefulness based upon their soundness
Derrick, John, Eerke Boiten, Derrick, J., Boiten, Eerke Albert, John Derrick, Boiten, Eerke, Boiten, E.   +6 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Security specification: completeness, feasibility, refinement [PDF]

, 2010
The formal methods and refinement community should be able to contribute to the specification and verification of security protocols. This talk describes a few of the essential differences, or problems.
Boiten, Eerke Albert
core  

Effect of Al addition on microstructure of AZ91D [PDF]

, 2014
Casting is a net shape or near net shape forming process so work-hardening will not be applicable for improving properties of magnesium cast alloys.
Joshi, U, Nadendla Hari Babu, Babu, NH, Utsavi Joshi   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The program of cultural refinement in 19th century Hungary: The Example of Count Széchenyi and Baron Kemény

ESPES, 2021
In an effort to give a historical depth to recent discussions on taste in Aesthetic theory, this paper recovers a 19th century Hungarian paradigm. While taste first came to the forefront of philosophical reflection with the Enlightenment and especially ...
Ferenc Horkay Hörcher
doaj