Results 21 to 30 of about 84,271 (219)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Geometric feature-enhanced reconstruction and refinement of photogrammetric mesh models in man-made environments

GIScience & Remote Sensing
The automatic reconstruction of photogrammetric mesh models often suffers from issues such as erroneous adhesion of different planes, local distortions, and the loss of edge details.
Min Chen, Tong Fang, Zelan Fu, Zhanhao Zhang, Kai Liu, Han Hu, Xuming Ge, Qing Zhu, Jianhui Gong   +8 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The Application of REV-LBM Double Mesh Local Refinement Algorithm in Porous Media Flow Simulation

Geofluids, 2022
REV-scale LBM (representative elementary volume scale lattice Boltzmann method) provides a possible way for the unified microscopic simulation of transscale seepage combined with pore-scale LBM.
Zhongkun Niu, Zhengming Yang, Yutian Luo, Yapu Zhang, Debin Xia, Taiyi Zheng, Xinli Zhao   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Sequential Convex Programming for Reentry Trajectory Optimization Utilizing Modified hp-Adaptive Mesh Refinement and Variable Quadratic Penalty

Aerospace
Due to the strong nonlinearity in the reentry trajectory planning problem for reusable launch vehicles (RLVs), the scale of the problem after high-precision discretization can become significantly large, and the non-convex path constraints are prone to ...
Zhe Liu, Naigang Cui, Lifu Du, Jialun Pu
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Entry Guidance for Hypersonic Glide Vehicles via Two-Phase hp-Adaptive Sequential Convex Programming

Aerospace
This paper addresses the real-time trajectory generation problem for hypersonic glide vehicles (HGVs) during atmospheric entry, subject to complex constraints including aerothermal limits, actuator bounds, and no-fly zones (NFZs).
Xu Liu, Xiang Li, Houjun Zhang, Hao Huang, Yonghui Wu   +4 more
doaj   +1 more source