Results 41 to 50 of about 297,066 (279)

Ultra-high resolution X-ray structure of orthorhombic bovine pancreatic Ribonuclease A at 100K

BMC Chemistry, 2023
The crystal structure of orthorhombic Bovine Pancreatic Ribonuclease A has been determined to 0.85 Å resolution using low temperature, 100 K, synchrotron X-ray data collected at 16000 keV (λ = 0.77 Å). This is the first ultra-high-resolution structure of
David R. Lisgarten, Rex A. Palmer, Jon B. Cooper, Claire E. Naylor, Rosemary C. Talbert, Brendan J. Howlin, John N. Lisgarten, Janez Konc, Shabir Najmudin, Carina M. C. Lobley   +9 more
doaj   +1 more source

Biomolecular structure refinement based on adaptive restraints using local-elevation simulation [PDF]

Journal of Biomolecular NMR, 2007
ISSN:0925 ...
Christen, Markus, Keller, Bettina, van Gunsteren, Wilfred F.   +2 more
openaire   +4 more sources

Vertical restraints and competition policy [PDF]

, 1996
This report considers the private and social welfare effects of vertical restraints - whereby contractual arrangements between suppliers (manufacturers) and distributors (retailers) extend beyond simple arms-length pricing.
Dobson, Paul, Waterson, Michael, Paul W Dobson, Michael Waterson   +3 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Automatic forward model parameterization with Bayesian inference of conformational populations [PDF]

APL Machine Learning
To quantify how well theoretical predictions of structural ensembles agree with experimental measurements, we depend on the accuracy of forward models (FMs).
Robert M. Raddi, Tim Marshall, Vincent A. Voelz   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Acute Deep Deltoid Ligament Reconstruction using a Novel, Arthroscopically-Assisted Technique: Case Report

Foot & Ankle Orthopaedics, 2022
Category: Arthroscopy; Ankle; Sports; Trauma Introduction/Purpose: The deltoid ligament complex is the main stabilizing structure of the ankle mortise and is often disrupted in rotational ankle injuries. Current treatment involves open techniques for the
Casey W. Pyle DO, Edward J. McDonald DO, Frederic J. Washburn DO, Dennis Horvath DO   +3 more
doaj   +1 more source

Improving macromolecular structure refinement with metal-coordination restraints

Acta Crystallographica Section D Structural Biology
Metals are essential components for the structure and function of many proteins. However, accurate modelling of their coordination environments remains a challenge due to the complexity and diversity of metal-coordination geometries.
Kaveh H. Babai, Fei Long, Martin Malý, Keitaro Yamashita, Garib N. Murshudov   +4 more
openaire   +2 more sources

4096 Refined structure of human ferroportin using restraints from mass spectrometry [PDF]

Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: Mammals require iron for hemoglobin, respiration, immunity and as cofactor in enzymes. But free iron is toxic from the production of reactive oxygen species. Ferroportin is the sole exporter of cellular iron and it crucially determines cellular and systemic iron levels. Labile iron must be tightly regulated.
Christian S. Parry, Andrey Ivanov, Guelaguetza Vazquez-meves, Fatemah A. Alhakami, Jessika Agyepong, Kyungreem Han, Bernard R. Brooks, Sergei Nekhai   +7 more
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source