Results 61 to 70 of about 297,066 (279)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Time- and ensemble-averaged direct NOE restraints [PDF]
, 1994 NMR data are collected as time- and ensemble-averaged quantities. Yet, in commonly used methods for structure determination of biomolecules, structures are required to satisfy simultaneously a large number of constrainsts. Recently, however, methods have
Boelens, Rolf +2 more
core +3 more sources
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Bond Law ReviewThis article considers the High Court’s decision in EGH19 v Commonwealth of Australia, the latest development in the constitutional limits on executive restraints imposed on non-citizens following NZYQ and YBFZ.
Sachi Elliott
doaj +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2018 A large number of structural determinations of compounds containing 2-hydroxy-3,5-dinitrobenzoic acid (I) and its various deprotonated forms, 2-hydroxy-3,5-dinitrobenzoate (II) or 2-carboxy-4,6-dinitrophenolate (III), are biased.
Jan Fábry
doaj +1 more source
Structural studies into AM(_2)O(_7) framework materials and parametric Rietveld refinement [PDF]
, 2006 This thesis investigates the structural properties of the AM2O7 family of materials, many of which show interesting thermal expansion properties and remarkably complex structures.
Stinton, Graham William
core
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
FEBS Open Bio, EarlyView.Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source
Fred Keller Goes to Law School
Legal Education Review, 1991 It seems axiomatic among some law teachers that small group “Socratic” teaching in one form or another is a superior teaching method. 1 Unfortunately, when taught to small groups it is also an expensive teaching method.
Shirley L Rawson, Alan L Tyree
doaj +1 more source
IUCrJ, 2014 Hirshfeld atom refinement (HAR) is a method which determines structural parameters from single-crystal X-ray diffraction data by using an aspherical atom partitioning of tailor-made ab initio quantum mechanical molecular electron densities without any ...
Silvia C. Capelli +4 more
doaj +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source