Results 51 to 60 of about 297,066 (279)

Human Skeletal Stem Cell Response to Multiscale Topography Induced by Large Area Electron Beam Irradiation Surface Treatment

Frontiers in Bioengineering and Biotechnology, 2018
The healthcare socio-economic environment is irreversibly changing as a consequence of an increasing aging population, consequent functional impairment, and patient quality of life expectations.
Vitali Goriainov, Richard B. Cook, James W. Murray, John C. Walker, Douglas G. Dunlop, Adam T. Clare, Richard O. C. Oreffo   +6 more
doaj   +1 more source

In situ ligand restraints from quantum-mechanical methods [PDF]

, 2023
In macromolecular crystallographic structure refinement, ligands present challenges for the generation of geometric restraints due to their large chemical variability, their possible novel nature and their specific interaction with the binding pocket of ...
Moriarty, Nigel W, Adams, Paul D, Liebschner, Dorothee, Poon, Billy K   +3 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER [PDF]

Acta Crystallographica Section D Biological Crystallography, 2012
Maximum-likelihood X-ray macromolecular structure refinement inBUSTERhas been extended with restraints facilitating the exploitation of structural similarity. The similarity can be between two or more chains within the structure being refined, thus favouring NCS, or to a distinct `target' structure that remains fixed during refinement.
Smart, Oliver S., Womack, Thomas O., Flensburg, Claus, Keller, Peter, Paciorek, Włodek, Sharff, Andrew, Vonrhein, Clemens, Bricogne, Gérard   +7 more
openaire   +2 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

ResDe: a new tool for visual definition of distance restraints for crystallographic refinement

, 2010
Manually defined distance restraints can be useful during structure refinement, particularly in low-resolution refinement where the additional restraints are needed to maintain appropriate stereochemical geometry.
Sean J. Johnson, Bradley J. Hintze
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Conformation-dependent backbone geometry restraints set a new standard for protein crystallographic refinement

Ideal values of bond angles and lengths used as external restraints are crucial for the successful refinement of protein crystal structures at all but the highest of resolutions.
Adams, Paul D., Karplus, P. Andrew, Moriarty, Nigel W., Tronrud, Dale E.   +3 more
core   +6 more sources

MARTINI-Based Protein-DNA Coarse-Grained HADDOCKing

Frontiers in Molecular Biosciences, 2019
Modeling biomolecular assemblies is an important field in computational structural biology. The inherent complexity of their energy landscape and the computational cost associated with modeling large and complex assemblies are major drawbacks for ...
Rodrigo V. Honorato, Rodrigo V. Honorato, Jorge Roel-Touris, Alexandre M. J. J. Bonvin   +3 more
doaj   +1 more source