Results 81 to 90 of about 25,163 (292)

Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation

Dermatology Practical & Conceptual, 2017
Grover’s disease is a benign condition of unknown origin characterized clinically by an erythematous papulovesicular eruption and histopathologically by intraepidermal clefting and four different patterns of acantholysis: Darier-like, pemphigus-like ...
Francesco Lacarrubba, Simona Boscaglia, Maria Rita Nasca, Rosario Caltabiano, Giuseppe Micali   +4 more
doaj   +1 more source

Rapid Stereomicroscopic Imaging of HER2 Overexpression in Ex Vivo Breast Tissue Using Topically Applied Silica-Based Gold Nanoshells [PDF]

, 2012
Tumor margin detection for patients undergoing breast conservation surgery primarily occurs postoperatively. Previously, we demonstrated that gold nanoshells rapidly enhance contrast of HER2 overexpression in ex vivo tissue sections.
Agollah, Germaine D., Bickford, Lissett R., Chang, Joseph, Drezek, Rebekah, Kennedy, Laura C., Langsner, Robert J.   +5 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Robust 3D Surface Recovery by Applying a Focus Criterion in White Light Scanning Interference Microscopy

, 2019
White light scanning interference (WLSI) microscopes provide an accurate surface topography of engineered surfaces. However, the measurement accuracy is substantially reduced in surfaces with low-reflectivity regions or high roughness, like a surface ...
Altamar-Mercado, Hernando, Marrugo, Andres G, Patiño-Vanegas, Alberto   +2 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Dermoscopic and reflectance confocal microscopy features of two cases of vulvar basal cell carcinoma [PDF]

, 2018
Basal cell carcinoma (BCC) is the most common malignant skin cancer. Its genital localization is rare, and the diagnosis in this site could be challenging.
Cinotti, Elisa, Habougit, Cyril, Luisi, Stefano, Perrot, Jean Luc, Rubegni, Pietro, Tonini, Giulia   +5 more
core   +2 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

A Compact Laser Imaging System for Concurrent Reflectance Confocal Microscopy and Laser Doppler Flowmetry

IEEE Photonics Journal, 2016
We propose a compact laser feedback interferometry imaging system for concurrent reflectance confocal microscopy and laser Doppler flowmetry. This system acquires both confocal reflectance and Doppler signals in a confocal architecture to image dynamic ...
Alireza Mowla, Thomas Taimre, Yah Leng Lim, Karl Bertling, Stephen J. Wilson, Tarl W. Prow, Aleksandar D. Rakic   +6 more
doaj   +1 more source

Topological characterization of antireflective and hydrophobic rough surfaces: are random process theory and fractal modeling applicable? [PDF]

, 2015
The random process theory (RPT) has been widely applied to predict the joint probability distribution functions (PDFs) of asperity heights and curvatures of rough surfaces.
Borri, Claudia, Paggi, Marco
core   +2 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source