Results 91 to 100 of about 182,084 (332)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Summary of dermoscopic features, reflectance confocal microscopy and histopathologic aspects.

, 2013
Summary of dermoscopic features, reflectance confocal microscopy and histopathologic aspects.
Juliana Casagrande Tavoloni Braga (493214), Gisele Gargantini Rezze (493219), Giovanni Pellacani (266366), João Duprat (493217), Mariana Petaccia Macedo (493215), Maria Dirlei Begnami (493218), Clovis Pinto (493216)   +6 more
core   +1 more source

In vivo reflectance confocal microscopy features of a melanoacanthoma

Dermatology Practical & Conceptual, 2016
Efforts have been expended to evaluate the reflectance confocal microscopy (RCM) features of different clinical entities in order to more thoroughly delineate benign versus malignant features.
Neda Shahrian, Jane M. Grant-Kels, Harold S. Rabinovitz, Margaret Oliviero, Alon Scope   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Coherent Backscatter Enhances Reflection Confocal Microscopy [PDF]

BioTechniques, 1998
When thin optically transparent specimens are grown on reflective substrates, contrast in reflection confocal microscopy is markedly enhanced. This enhanced contrast allows for the visualization of the thin filopodia and organelles contained within the neuritic processes of PC12 cells in culture. The characteristics of this contrast enhancement suggest
Charles H. Keith, Glenn J. Bird, Mark A. Farmer   +2 more
openaire   +3 more sources

In Vivo Reflectance Confocal Microscopy in General Dermatology: How to Choose the Right Indication

Dermatology Practical & Conceptual, 2020
Reflectance confocal microscopy (RCM) is a high-resolution, noninvasive imaging technique being increasingly used as an aid to diagnosis in the dermatology setting. RCM is applied in the diagnosis of both melanoma and nonmelanoma skin tumors, but also in
C. Franceschini, F. Persechino, M. Ardigó   +2 more
semanticscholar   +1 more source

Assessment of skin photoaging with reflectance confocal microscopy

, 2014
Background/Purpose: Increased interest in antiaging methods, mandates a development of reliable noninvasive technique to assess skin aging. In this study, we aimed to determine the effects of photoaging at histopathologic resolution by means of ...
Erdemir, A., N. S. Kutlu Haytoglu, M. S. Gurel, A. Dolgun, Gurel, M. S., T. Falay, Dolgun, A., Haytoglu, T. G., Falay, T., A. Erdemir, T. G. Haytoglu, Haytoglu, N. S. Kutlu   +11 more
core   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Reflectance confocal microscopy features of thin versus thick melanomas

, 2019
In vivo reflectance confocal microscopy (RCM) plays an increasingly important role in differential diagnosis of melanoma. The aim of the study was to assess typical confocal features of thin (≤1mm according to Breslow index) versus thick (>1mm ...
Olszewska, Małgorzata, Rudnicka, Lidia, de Carvalho, Nathalie, Kardynal, Agnieszka, Walecka, Irena, Pellacani, Giovanni   +5 more
core   +1 more source