Results 101 to 110 of about 182,084 (332)

A pulse coupled neural network segmentation algorithm for reflectance confocal images of epithelial tissue.

PLoS ONE, 2015
Automatic segmentation of nuclei in reflectance confocal microscopy images is critical for visualization and rapid quantification of nuclear-to-cytoplasmic ratio, a useful indicator of epithelial precancer.
Meagan A Harris, Andrew N Van, Bilal H Malik, Joey M Jabbour, Kristen C Maitland   +4 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Biopsy outperforms reflectance confocal microscopy in diagnosing and subtyping basal cell carcinoma: results and experiences from a randomized controlled multicentre trial

British Journal of Dermatology, 2020
Reflectance confocal microscopy (RCM) is a noninvasive method for skin assessment, allowing entire lesion evaluation up to the papillary dermis. RCM is a potentially attractive alternative to punch biopsy (PB) in basal cell carcinoma (BCC).
W. Weg, M. Peppelman, Y. Elshot, Y. Elshot, M. Visch, M. Crijns, H. Alkemade, E. Bronkhorst, Eddy M. M. Adang, A. Amir, M. P. Gerritsen, P. V. Erp, S. Lubeek   +12 more
semanticscholar   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Reflectance confocal microscopy for the evaluation of solitary red nodules

, 2012
The correct assessment of a solitary red nodule in clinical practice is of crucial importance, amelanotic melanoma being the most important differential diagnosis.
Ardigo M., Vega Hernando, Moscarella E, ARGENZIANO, Giuseppe, Zalaudek I, Moscarella Elvira, Ardigo Marco, Argenziano Giuseppe, Vega H, Cota Carlo, Catricala Caterina, Agozzino Marina, Catricalà C, Cota C, Agozzino M   +14 more
core   +1 more source

Reflectance confocal microscopy terminology glossary for melanocytic skin lesions: A systematic review

, 2020
There is lack of uniformity in the reflectance confocal microscopy (RCM) terminology for melanocytic ...
Monnier, Jilliana, Jain, Manu, Navarrete-Dechent, Cristian, Liopyris, Konstantinos, Halpern, Allan C, Longo, Caterina, Boyce, Lindsay M, Aleissa, Saud, Rabinovitz, Harold, Oliviero, Margaret, Marghoob, Ashfaq A, Scope, Alon, Pellacani, Giovanni   +12 more
core   +1 more source

Value of reflectance confocal microscopy for the monitoring of rosacea during treatment with topical ivermectin

Journal of dermatological treatment (Print), 2020
Background Reflectance confocal microscopy (RCM) enables noninvasive Demodex mite detection in rosacea. Objective scoring of rosacea severity is currently lacking. Objectives To determine the value of RCM for monitoring Demodex, inflammation and vascular
J. Logger, M. Peppelman, P. van Erp, E. D. De Jong, K. Nguyen, R. Driessen   +5 more
semanticscholar   +1 more source

Nevomelanocytic atypia detection by in vivo reflectance confocal microscopy

Medicina, 2014
Background and objective: In vivo reflectance confocal microscopy (RCM) is a promising novel technology for non-invasive early diagnostics of cutaneous melanoma.
Ingrida Vaišnorienė, Ričardas Rotomskis, Vytautas Kulvietis, Rimantas Eidukevičius, Violeta Žalgevičienė, Aida Laurinavičienė, Jonas Venius, Janina Didžiapetrienė   +7 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

In Vivo Reflectance Confocal Microscopy-Diagnostic Criteria for Actinic Cheilitis and Squamous Cell Carcinoma of the Lip

Journal of Clinical Medicine, 2020
Actinic cheilitis (AC) is one of the most frequent pathologies to affect the lips. Studies show that the most commonplace oral malignancy, squamous cell carcinoma (SCC), often emerges from AC lesions.
M. Lupu, A. Căruntu, D. Boda, C. Caruntu   +3 more
semanticscholar   +1 more source