Results 111 to 120 of about 1,810,512 (351)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The borderlands of waking:quantifying the transition from reflective thought to hallucination in sleep onset [PDF]

, 2016
We lose waking consciousness spontaneously and regularly over the circadian cycle. It seems that every time we fall asleep, reflective thinking gradually gives way to our interactions with an imaginary, hallucinatory world that brings multimodal ...
Ajilore, Antrobus, Cantero, Casagrande, Casagrande, Casagrande, Casagrande, Casagrande, Casagrande, Clemens Speth, Fosse, Gruber, Hobson, Jana Speth, Moon, Reinhart, Reinhart, Rowley, Silbersweig, Speth, Speth, Stickgold, Violani, Windt   +23 more
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Vocational training and knowledge development:a deeper understanding [PDF]

, 2016
Construction management research literature has identified the importance of understanding the practical realities of skills and training provision and the role of reflective practice in the development of knowledge.
Blackwood, David J., Gilmour, Daniel J., Logan, George, McCallum, Claire, Simpson, Edward   +4 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

PENGARUH PEMBELAJARAN DENGAN PENDEKATAN SCIENTIFIC TERHADAP PENINGKATAN KEMAMPUAN BERPIKIR REFLEKTIF MATEMATIS SISWA SMP [PDF]

, 2014
Penelitian ini dilatarbelakangi rendahnya kemampuan berpikir reflektif matematis siswa SMP. Penelitian ini bertujuan untuk: 1) mengetahui apakah terdapat peningkatan kemampuan berpikir reflektif matematis siswa yang diberikan pembelajaran dengan ...
Rohyani, Annisa
core  

Measuring Teachers Reflective Thinking Skills

Procedia - Social and Behavioral Sciences, 2014
AbstractObservation, communication, team working, judgment, and decision making are important teaches reflective thinking skills that are required for teachers if they want to be reflective thinker. This paper proposes two instruments which are Reflective Thinking Open-Ended Questionnaire and Interview Questionnaire to measure teachers’ reflective ...
Mirzaei, Fariba, Phang, Fatin Aliah, Kashefi, Hamidreza   +2 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Reflective journal writing: How it promotes reflective thinking in clinical nursing education: A students’ perspective

Curationis, 2002
According to the outcomes-based education and training system of education (OBET) in the country and the South African Nursing Council, education should focus on “creating” reflective learners and practitioners.
J. Kok, M.M. Chabeli
doaj   +1 more source