Results 91 to 100 of about 73,554 (292)

Functional state of peripheral nerves of lower limbs in patients with deforming knee joint arthrosis

Acta Biomedica Scientifica, 2018
With osteochondrosis of the lumbar spine and L3, L4 lesions, local overloads of the spinal-motor segment lead to disruption of the functioning of the biokinematic chain "spine-lower limbs".
T. K. Verkhozina, E. G. Ippolitova, N. I. Arsentieva, E. S. Tsyslyak   +3 more
doaj   +1 more source

N, S Co‐Doped Carbon Quantum Dots‐Riboflavin Composite Photosensitizers for Enhanced Iontophoresis‐Assisted Corneal Cross‐Linking

Advanced Science, EarlyView.
This study explores the use of N, S co‐doped carbon quantum dots (NS‐CQDs) as carriers for riboflavin, creating NS‐CQDs‐RF composite photosensitizers. These composites improve riboflavin absorption, enhance ROS generation efficiency, and preserve corneal epithelium integrity.
Tinghong Xu, Yong Liu, Wenjing Zhang, Qiuruo Jiang, Yi Jin, Liangzheng Lin, Lumeng Wang, Zhanhao Gu, Mimi Lin, Shihao Chen   +9 more
wiley   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

A model of the cerebellum generates gait adaptations in a reflex-based neuromusculoskeletal model during split-belt walking

Journal of NeuroEngineering and Rehabilitation
Background During split-belt treadmill walking, neurotypical humans exhibit adaptations characterized by a gradual decrease in step length asymmetry (SLA) toward or beyond symmetry, whereas individuals with cerebellar damage do not show these motor ...
Sophie Fleischmann, Julian Shanbhag, Joerg Miehling, Sandro Wartzack, Carmichael Ong, Bjoern M. Eskofier, Anne D. Koelewijn   +6 more
doaj   +1 more source

Effect of intervertebral disc disease on scoliosis in the lumbar spine

Current Issues in Pharmacy and Medical Sciences, 2014
Lumbar intervertebral discopathy is a common clinical problem and a significant cause of low back pain. Usually it is associated with overload and damage to the intervertebral disc, which directly relates to the instability of the motion segment.
Wojcik Gustaw, Piskorz Jolanta, Ilzecka Joanna, Bulikowski Wlodzimierz   +3 more
doaj   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Differences in five kilometer time trial performance during the recovery period after an ultramarathon race

, 2013
Includes abstract.Includes bibliographical references.Athletes require an appropriate balance between training, competition stress and recovery to achieve maximal performance. Previous studies have shown that exercise induced muscle damage has a negative
Benney, Tamlyn
core  

Effects of clothianidin exposure during pregnancy and lactation on the thyroid function of maternal rats and the early neurodevelopment of offspring

Guangxi Yike Daxue xuebao
Objective To investigate the effects of clothianidin (CLO) exposure on the thyroid function of mater‐nal rats and the early neurodevelopment of their offspring by establishing a CLO exposure model in SpragueDawley (SD) rats during pregnancy and lactation.
Xiaorong HUANG, Wanhui LI, Junshang WEN, Liujuan OU, Junwang GU, Huishen HUANG, Ying YANG, Qihua ZHU, Kaiqi YANG, Xin QIN, Dongping HUANG   +10 more
doaj   +1 more source